Dr Matthias Bruhn awarded doctoral prize by the HZI Förderverein
Award ceremony as part of the Inhoffen Lecture on 13 June 2024
Immunology
Kalinke Lab
Projects
Here you can gain an insight into the projects of the Kalinke Lab in the field of immunology. In particular, immune responses in acute hepatitis and encephalitis are being investigated in order to develop innovative therapies on this basis.
Kalinke Lab
Immunology
Immunological sensing of cytomegalovirus (CMV)
The project investigates how HCMV is recognized by the immune system and which mechanisms the virus uses to camouflage itself. The aim is to understand the immune reactions and develop therapies for severely affected patients.
Kalinke Lab
Immunology
Regulation of acute hepatitis
The project investigates immune reactions in viral hepatitis, in particular the role of hepatocytes and myeloid cells. The aim is to understand immune processes in the liver and to develop diagnostic approaches for the clinic.
Kalinke Lab
Immunology
Virus control within the CNS
The project investigates the immune response of the central nervous system in viral infections, in particular the role of type I IFN, microglia and monocytes in the development of encephalitis and their influence on seizures and hippocampal damage.
Kalinke Lab
Immunology
Towards the molecular mechanism of HBV vaccination non-responsiveness
The project will investigate the immunological and genetic causes of vaccination failure in 5% of HBV-vaccinated individuals in order to develop new strategies to improve vaccination protection.
Kalinke Lab
Immunology
Cell-selective delivery of active compounds
The project is developing methods to specifically transport antibiotics into cells such as alveolar macrophages, which are important in Mycobacterium tuberculosis infections. The aim is to overcome resistance and reduce side effects.
Kalinke Lab
Immunology
Towards the development of novel cell therapy options for MSMD patients
The project is developing iPSC-based therapies for MSMD patients, a genetic disease with mutations in the IFN-γ signaling pathway that lead to severe mycobacterial infections. The aim is to improve the treatment prognosis.
Posts
Doctoral Prize of the Friends of the MHH goes to Dr Bibiana Costa
TWINCORE scientist honoured for outstanding doctoral thesis.
17 December 2013 Trojan horse for the treatment of tuberculosis
25 September 2013 HAI at TWINCORE
Forschen zwischen Grundlagen und Zulassung - Neue Forschungsrichtung am TWINCORE
Start-up funding for antibody project
MEMUMAB research project receives GO-Bio initial funding / Kickoff on 22 November
New approaches to research into systemic sclerosis
A research team at TWINCORE was able to establish that TLR8 influences the formation of disease-relevant cytokines.
More than the sum of the parts
TWINCORE researchers show role of epistatic interaction in the omicron variant of SARS-CoV-2 virus .
Diversity is the key
How B cells recognise new variants of SARS-CoV-2
Hijacking in the immune system
HCMV reprograms cellular defence mechanisms
How pollen increases susceptibility to virus infection
TWINCORE researchers describe how birch pollen affects immune cells
Vaccination success without B cells
Communication between immune cells determines response to vaccination
A call for help from the brain
How immune cells are lured to the brain in encephalitis
A Trojan horse against tuberculosis
New transport route for antibiotics directly into infected cells
How cytomegaloviruses are kept in check
Important mechanism of antigen presentation in guard cells of the immune system riddled
New inhibition mechanism for Human Cytomegalovirus
Does the liver fend heard muscle inflammation caused by Coxsackieviruses?
Hepatitis therapy: balance between defence and regeneration via Kupffer cells
Virus infections of bone marrow donors influence the outcome of transplantations
New perspectives for research on hepatitis C virus
Mode of action of a novel RNA-adjuvants detected – successful collaboration with the CureVac AG
TWINCORE scientists identified cause of susceptibility to infection in rheumatism patients
Cytomegalie research with human cells - on the trail of HCMV
Olfactory bulbs as a branch of the immune system - the olfactory brain defends independently against viruses
A direct view into the "control center" of the immune system
6 November 2014 Magic cap lifted - TWINCORE scientists decode a new camouflage mechanism of cytomegalovirus
3 September 2014 Mechanisms of interferon production explored - New perspectives for the defense against serious infectious diseases
Where does the interferon for the early virus defence come from?
7 February 2014 Antibodies as drugs - New prediction systems for the reaction in humans
10 October 2013 Admission requirements for individual cancer therapies published in Nature Biotech
28 September 10 Neuer Mechanismus bei der Virenabwehr entdeckt: Interferon macht das spezifische Immunsystem gegen Viren mobil
Better results through less stress
Researchers in Hannover have developed a new method for studying neuroinfections.
New junior research group "Translational Immunology
Clinician scientist Theresa Graalmann starts her own group at TWINCORE
