Marco Galardini appointed W2 professor at TWINCORE
Inaugural lecture on 6 March 2026
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Lower Saxony International Summer Academy 2026
The LISA Summer School 2026 takes place from 23 August to 11 September 2026. Registration is open until 31 March.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Communications Biology : 10.1038/s42003-026-09724-6
NRF2 activators and the inhibitor of nuclear export, selinexor, restrict coronaviruses by targeting a network involving ACE2, TMPRSS2, and XPO1 through an NRF2-independent mechanism
Waqas F, S da Costa L, Zapatero-Belinchón F, Carter-Timofte M, Lasswitz L, van der Horst D, Möller R, Dahlmann J, Olmer R, Geffers R, Gerold G, Olagnier D, Pessler F
2026The Journal of Clinical Investigation136 (4) : e192371
Type I IFN-dependent FcγRIV signaling in murine monocytes promotes lethal anaphylaxis during viral infections
Elwy A, Abdelrahman H, Specht J, Ewert G, Friebus-Kardash J, Dhiman S, Falkenstein J, Christ T, Wiebeck E, Shamoon A, Leimkühler N, Gramberg T, Russ A, Kalinke U, Kuang F, Sutter K, Kopf M, Mack M, Hansen W, Nimmerjahn F, Lang K
2026Nature Communications : 10.1038/s41467-026-69412-1
Opposite effects of chronic HIV infection and antiretroviral medication on organismal and organ-specific biological aging
Zhang Y, Matzaraki V, Vadaq N, Blaauw M, Vos W, Groenendijk A, van Eekeren L, Stalenhoef J, Berrevoets M, Rokx C, Delporte M, Otten T, Joosten L, Xu C, Li Y, Vandekerckhove L, van der Ven A, Netea M
Kalinke Lab
Immunology
Immunological sensing of cytomegalovirus (CMV)
The project investigates how HCMV is recognized by the immune system and which mechanisms the virus uses to camouflage itself. The aim is to understand the immune reactions and develop therapies for severely affected patients.
Kalinke Lab
Immunology
Towards the molecular mechanism of HBV vaccination non-responsiveness
The project will investigate the immunological and genetic causes of vaccination failure in 5% of HBV-vaccinated individuals in order to develop new strategies to improve vaccination protection.
Kalinke Lab
Immunology
Towards the development of novel cell therapy options for MSMD patients
The project is developing iPSC-based therapies for MSMD patients, a genetic disease with mutations in the IFN-γ signaling pathway that lead to severe mycobacterial infections. The aim is to improve the treatment prognosis.
Galardini Lab
Bacteriology
Pangenome wide prediction of gene function
Thanks to high-throughput sequencing, genome sequences of hundreds of bacterial strains can be analyzed efficiently, revealing differences of up to 60 % in gene content, as in E. coli. With the help of machine learning, we want to better predict the functions of accessory genes and decipher their contribution to survival in specialized niches.
Seminar
TWINCORE Seminar
Prof. Makoto Takeda
Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan
“Host protease-mediated activation of respiratory viruses: From the laboratory bench to the frontlines of infectious disease control”
Lecture Series - Regulatory Science and Translational Research - Part 5
Postponed - new date will be announced soon.
Lecture Series - Regulatory Science and Translational Research - Part 6
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
