Optimised active substances against RSV
OPERA research project launched to further develop antiviral active substances
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Lower Saxony International Summer Academy 2026
The LISA Summer School 2026 takes place from 23 August to 11 September 2026. Registration is open until 31 March.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Journal of Clinical Microbiology : e0104425
Genomic epidemiology of Enterococcus faecium bloodstream infections during a VanB-type VRE peak reveals an oligoclonal scenario: an observational study at a German university hospital (2017-2022)
Knegendorf L, Sommer A, Baier C, Weber R, Fischer M, Werner G, Ziesing S, Schlüter D
2026International Journal of Cancer : 10.1002/ijc.70427
ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance
Sánchez-Maldonado J, Macauda A, Cabrera-Serrano A, Thomsen H, Güler M, Horst R, van Guelpen B, Vodicka P, Landi S, Chattopadhyay S, Ünal P, Ruiz-Durán L, Casabonne D, Goldschmidt H, Serin I, Carretero-Fernández M, Cabezudo E, Reyes-Zurita F, Norman A, García-Sanz R, Capurso G, Hoffmann P, Pettersson-Kymmer U, Jiménez-Romera F, Rajkumar S, Weinhold N, Vodickova L, Langer C, Stein A, Karismaz A, Moreno V, Nöthen M, Jöckel K, Tavano F, Martínez-López J, Kumar S, Gutiérrez-Bautista J, Basso D, Späth F, Benavente Y, Hildebrandt M, Schmidt B, Sevcikova T, Reis R, Li Y, López-Nevot M, Netea M, Campa D, Clay-Gilmour A, Slager S, Hemminki K, Vachon C, Försti A, Canzian F, Sainz J
2026Communications Biology : 10.1038/s42003-026-09724-6
NRF2 activators and the inhibitor of nuclear export, selinexor, restrict coronaviruses by targeting a network involving ACE2, TMPRSS2, and XPO1 through an NRF2-independent mechanism
Waqas F, S da Costa L, Zapatero-Belinchón F, Carter-Timofte M, Lasswitz L, van der Horst D, Möller R, Dahlmann J, Olmer R, Geffers R, Gerold G, Olagnier D, Pessler F
Kalinke Lab
Immunology
Cell-selective delivery of active compounds
The project is developing methods to specifically transport antibiotics into cells such as alveolar macrophages, which are important in Mycobacterium tuberculosis infections. The aim is to overcome resistance and reduce side effects.
Pietschmann Lab
Virology
Mechanisms of HCV tissue and species tropism: A guide for development of animal models
The project investigates the factors that determine the species barrier mechanism of HCV and make it impossible to study the infection in animal models. The aim is to use genetic screening systems to develop in vivo models for vaccine research.
Pietschmann Lab
Virology
Host and viral factors that govern susceptibility to HCV and RSV
We are investigating why HCV infections sometimes heal spontaneously, but often become chronic, and why RSV infections are severe in some children. We use modern sequencing technologies to analyze the genetic characteristics of hosts and pathogens in order to understand susceptibility.
Behrendt Lab
Virology
Determinants of the Clinical Course of Infection
Human, potentially neutralizing antibodies against HEV have advanced the development of new detection methods for the virus in patient samples. Serological and functional analyses are used to determine markers for the course and treatment of chronic infections.
Lecture Series - Regulatory Science and Translational Research - Part 5
"Interaction with regulators, e.g. in preparation of a first clinical study"
Lecture Series - Regulatory Science and Translational Research - Part 6
"Challenge Orphan medicines – learnings from the past"
Lecture Series - Regulatory Science and Translational Research - Part 1
"Why is knowledge in regulatory science important for translational medicine and basic science?"
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
