Warm nights and ill premature babies?
A study from Hanover investigates the spread of Klebsiella in the neonatal intensive care unit.
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
TWINCORE Symposium 2026
This year's TWINCORE Symposium
Pathways to infection resilience
will take place on 3 - 4 September.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Plos Pathogens22 (7) : e1014355
Co-regulation of HIV control and cytomegalovirus pp65-specific IL-1β and TNF-α responses by genetic variants in the MHC region
Ruijten S, Dos Santos J, Rios-Vazquez V, Navas A, Maas H, Groenendijk A, Blaauw M, van Eekeren L, Vos W, Knoll R, Kumar Gupta M, Ter Horst R, Botey-Bataller J, van Unen N, Li Y, Aschenbrenner A, Schultze J, Xu C, Netea M, van der Ven A, Matzaraki V
2026Biomarker Research14 (1) : 82
Interleukin-10 enhances IgG galactosylation and sialylation
Lunding H, Wasynczuk A, Bartsch Y, Buhre J, Nouta J, Leliavski A, Lehrian S, Becker A, Manzhula K, Köcher P, Mehlfeld J, Rahmöller J, Wuhrer M, Ehlers M
2026Mbio : e0115126
Intra-host viral population dynamics during acute hepatitis E virus infection
Janshoff S, Plümers R, Kohl A, Nocke M, Behrendt P, Knabbe C, Costa R, Vollmer T, Todt D, Steinmann E, Gömer A
Kalinke Lab
Immunology
Virus control within the CNS
The project investigates the immune response of the central nervous system in viral infections, in particular the role of type I IFN, microglia and monocytes in the development of encephalitis and their influence on seizures and hippocampal damage.
Pietschmann Lab
Virology
Host and viral factors that govern susceptibility to HCV and RSV
We are investigating why HCV infections sometimes heal spontaneously, but often become chronic, and why RSV infections are severe in some children. We use modern sequencing technologies to analyze the genetic characteristics of hosts and pathogens in order to understand susceptibility.
Lauber Lab
Virology
Deep exploration of the virosphere for novel viruses in humans and other eukaryotes
Using high-performance computers, we analyze NGS data to discover unknown viruses in the human and animal virome that could influence disease risks. We investigate the virome as a factor for infections and diseases such as cancer and immunodeficiencies.
Galardini Lab
Bacteriology
Testing the impact of genetic backgrounds on antimicrobial resistance
Population genetic studies show that genetic variability between bacterial strains can influence the evolution of antimicrobial resistance. Using automated laboratory evolution (ALE), we are investigating how genetic backgrounds control AMR evolution.
Science and Society
Science and Society
Ralf Meister, Bishop of the Evangelical-Lutheran Church of Hanover
“Participation and Resilience at the Interface between Science and Society”
Symposium
TWINCORE & CiiM Symposium 2026
Pathways to Infection Resilience
Lecture Series - Regulatory Science and Translational Research - Part 1
"Why is knowledge in regulatory science important for translational medicine and basic science?"
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
