New findings on spinal muscular atrophy
Researchers investigate the impact on the immune system.
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Staying One Step Ahead of Resistance
How bacteria develop resistance to antisense antibiotics - and how future therapies can be designed to reduce the risk of resistance
Antibodies produced following the Ebola vaccination neutralise the current Bundibugyo virus variant
A team of researchers from Hamburg, Berlin, Göttingen and Hannover has provided evidence of possible cross-protection offered by an already authorised Zaire Ebola virus vaccine.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Journal of Virology : e0111726
Arp2/3 complex-dependent actin remodeling is required for efficient RSV uncoating in A549 cells
Xie E, Schubert M, Reeb J, Seligmann B, Schaks M, Müsken M, Steffen A, Stradal T, Haid S, Rottner K, Sieben C
2026Molecular Therapy : The Journal of the American Society of Gene Therapy : S1525-0016(26)00714-8
ACC1 inhibition enhances BCG-induced trained immunity by reprogramming Acetyl-CoA metabolism
Baydemir I, Nikolka F, Bulut Ö, Ferreira A, Kilic G, Geckin B, Kramer R, Cuenca-Escalona J, Floor E, Báez-Magaña M, Matzaraki V, Deckers J, Anbergen T, van Elsas Y, Beldman T, Moorlag S, Charlotte J de Bree L, Spanou V, Andriopoulou T, Li Y, Karagianni E, Novakovic B, Sohrabi Y, Joosten L, Hiller K, Domínguez-Andrés J
2026The Journal of Clinical Investigation : e203540
Immune Cell-Specific SMN Expression and Sustained Immune Alterations in Treated Spinal Muscular Atrophy
Tapken I, Rahmel-Stein K, Ehlers C, Cieri F, Detering N, Schüning T, Bjelica B, Mindermann C, Neuhoff S, Schmitt L, Leo M, Hagenacker T, Illsinger S, Di Schiavi E, Graalmann T, Petri S, Kalinke U, Claus P
Kalinke Lab
Immunology
Immunological sensing of cytomegalovirus (CMV)
The project investigates how HCMV is recognized by the immune system and which mechanisms the virus uses to camouflage itself. The aim is to understand the immune reactions and develop therapies for severely affected patients.
Bartsch Lab
Immunology
Protective anti-viral immunity – learning from natural examples
In this project, antibodies that help to ward off infections are being investigated in more detail. The aim is to find characteristics that have a protective effect against certain pathogens by comparing different antibody profiles in infections and vaccinations.
Behrendt Lab
Virology
Determinants of the Clinical Course of Infection
Human, potentially neutralizing antibodies against HEV have advanced the development of new detection methods for the virus in patient samples. Serological and functional analyses are used to determine markers for the course and treatment of chronic infections.
Lauber Lab
Virology
Pandemic preparedness: assessing spill-over risk of RNA viruses
The CoViPa consortium uses computer-assisted high-throughput virus discovery and evolutionary analyses to identify RNA viruses with high spillover risk and potential animal host reservoirs and to investigate new pathogenicity factors.
Seminar
TWINCORE Seminar - Systems Immunology
Dr. Verónica Durán
Stanford University School of Medicine, Stanford
"Age-dependent immune landscape in dengue infection and disease progression"
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Prof. Shirit Einav
Stanford University School of Medicine, Stanford
"Targeting an understudied lipid kinase to restore lysosomal function in viral infection and neurodegeneration"
Lecture Series - Regulatory Science and Translational Research - Part 1
"Why is knowledge in regulatory science important for translational medicine and basic science?"
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
