New phone system at TWINCORE
Some extension numbers have changed.
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Npj Vaccines : 10.1038/s41541-026-01390-3
Functional antibody signatures following therapeutic immunization in Simian and Human immunodeficiency virus infection
Ilan S, Bartsch Y, Jung W, Kliuchnikov E, Roy V, Bonifer R, Walker-Sperling V, Borducchi E, Nkolola J, Lauffenburger D, Stieh D, Barouch D, Julg B
2026Vaccine75 : 128241
The effect of BCG vaccination on systemic inflammation in neonates
Koeken V, Nissen T, Birk N, Boahen C, van Crevel R, Kumar V, Li Y, Aaby P, Benn C, Netea M
2026Nature Communications : 10.1038/s41467-025-67939-3
Longitudinal plasma proteomic signatures of elite and viremic spontaneous HIV controllers
Vadaq N, Groenendijk A, Dos Santos J, Mehta K, Wit F, Vos W, Blaauw M, van Eekeren L, Lambrechts L, Rutsaert S, Nelwan E, Xu C, Joosten L, de Mast Q, Matzaraki V, van Lunzen J, Rokx C, Verbon A, Netea M, Vandekerckhove L, van der Ven A
Graalmann Lab
Immunology
Indirect effects of immunomodulatory drugs
Immunomodulatory drugs for rheumatic diseases specifically influence immune cells and messenger substances. This project investigates their effect on immune responses in order to find individually suitable therapies.
Kalinke Lab
Immunology
Cell-selective delivery of active compounds
The project is developing methods to specifically transport antibiotics into cells such as alveolar macrophages, which are important in Mycobacterium tuberculosis infections. The aim is to overcome resistance and reduce side effects.
Pessler Lab
Immunology
Predictive biomarkers for a poor immune response to influenza vaccination in elderly individuals
Older people are at high risk of a poor immune response to the flu vaccine. Together with partners, we are looking for biomarkers and risk factors for this inadequate response and are investigating ways to improve the vaccination response.
Pietschmann Lab
Virology
Determinants of protective immunity in HCV: A gold standard for vaccine development
We are investigating how antibodies protect against HCV infection, in particular what properties they have during a healing infection. The aim is to identify antibodies that are important for an effective vaccine against HCV.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
