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Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Npj Vaccines : 10.1038/s41541-026-01390-3
Functional antibody signatures following therapeutic immunization in Simian and Human immunodeficiency virus infection
Ilan S, Bartsch Y, Jung W, Kliuchnikov E, Roy V, Bonifer R, Walker-Sperling V, Borducchi E, Nkolola J, Lauffenburger D, Stieh D, Barouch D, Julg B
2026Vaccine75 : 128241
The effect of BCG vaccination on systemic inflammation in neonates
Koeken V, Nissen T, Birk N, Boahen C, van Crevel R, Kumar V, Li Y, Aaby P, Benn C, Netea M
2026Nature Communications : 10.1038/s41467-025-67939-3
Longitudinal plasma proteomic signatures of elite and viremic spontaneous HIV controllers
Vadaq N, Groenendijk A, Dos Santos J, Mehta K, Wit F, Vos W, Blaauw M, van Eekeren L, Lambrechts L, Rutsaert S, Nelwan E, Xu C, Joosten L, de Mast Q, Matzaraki V, van Lunzen J, Rokx C, Verbon A, Netea M, Vandekerckhove L, van der Ven A
Kalinke Lab
Immunology
Immunological sensing of cytomegalovirus (CMV)
The project investigates how HCMV is recognized by the immune system and which mechanisms the virus uses to camouflage itself. The aim is to understand the immune reactions and develop therapies for severely affected patients.
Pessler Lab
Immunology
Predictive biomarkers for a poor immune response to influenza vaccination in elderly individuals
Older people are at high risk of a poor immune response to the flu vaccine. Together with partners, we are looking for biomarkers and risk factors for this inadequate response and are investigating ways to improve the vaccination response.
Pietschmann Lab
Virology
Mechanisms of HCV tissue and species tropism: A guide for development of animal models
The project investigates the factors that determine the species barrier mechanism of HCV and make it impossible to study the infection in animal models. The aim is to use genetic screening systems to develop in vivo models for vaccine research.
Galardini Lab
Bacteriology
Pangenome wide prediction of gene function
Thanks to high-throughput sequencing, genome sequences of hundreds of bacterial strains can be analyzed efficiently, revealing differences of up to 60 % in gene content, as in E. coli. With the help of machine learning, we want to better predict the functions of accessory genes and decipher their contribution to survival in specialized niches.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
