Staying One Step Ahead of Resistance
How bacteria develop resistance to antisense antibiotics - and how future therapies can be designed to reduce the risk of resistance
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
TWINCORE Symposium 2026
This year's TWINCORE Symposium
Pathways to infection resilience
will take place on 3 - 4 September.
Antibodies produced following the Ebola vaccination neutralise the current Bundibugyo virus variant
A team of researchers from Hamburg, Berlin, Göttingen and Hannover has provided evidence of possible cross-protection offered by an already authorised Zaire Ebola virus vaccine.
Booster vaccination strengthens existing defences
Memory B cells play a key role in adapting to new coronavirus variants
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Journal of Virology : e0111726
Arp2/3 complex-dependent actin remodeling is required for efficient RSV uncoating in A549 cells
Xie E, Schubert M, Reeb J, Seligmann B, Schaks M, Müsken M, Steffen A, Stradal T, Haid S, Rottner K, Sieben C
2026Molecular Therapy : The Journal of the American Society of Gene Therapy : S1525-0016(26)00714-8
ACC1 inhibition enhances BCG-induced trained immunity by reprogramming Acetyl-CoA metabolism
Baydemir I, Nikolka F, Bulut Ö, Ferreira A, Kilic G, Geckin B, Kramer R, Cuenca-Escalona J, Floor E, Báez-Magaña M, Matzaraki V, Deckers J, Anbergen T, van Elsas Y, Beldman T, Moorlag S, Charlotte J de Bree L, Spanou V, Andriopoulou T, Li Y, Karagianni E, Novakovic B, Sohrabi Y, Joosten L, Hiller K, Domínguez-Andrés J
2026The Journal of Clinical Investigation : e203540
Immune Cell-Specific SMN Expression and Sustained Immune Alterations in Treated Spinal Muscular Atrophy
Tapken I, Rahmel-Stein K, Ehlers C, Cieri F, Detering N, Schüning T, Bjelica B, Mindermann C, Neuhoff S, Schmitt L, Leo M, Hagenacker T, Illsinger S, Di Schiavi E, Graalmann T, Petri S, Kalinke U, Claus P
Graalmann Lab
Immunology
Indirect effects of immunomodulatory drugs
Immunomodulatory drugs for rheumatic diseases specifically influence immune cells and messenger substances. This project investigates their effect on immune responses in order to find individually suitable therapies.
Graalmann Lab
Immunology
Cell-selective targeting of immune cells
Immunomodulatory drugs can have systemic side effects. This project is testing nanocarriers that deliver drugs specifically into myeloid immune cells in order to reduce side effects and increase the local effect.
Pietschmann Lab
Virology
Determinants of protective immunity in HCV: A gold standard for vaccine development
We are investigating how antibodies protect against HCV infection, in particular what properties they have during a healing infection. The aim is to identify antibodies that are important for an effective vaccine against HCV.
Pietschmann Lab
Virology
Antiviral agents against HCV, RSV and coronavirus
We develop high-throughput screening assays to identify antiviral molecules against RSV and SARS-CoV-2. We use compound libraries, investigate new mechanisms of action and strive for innovative therapies.
Seminar
TWINCORE Seminar
Prof. Naglaa Shoukry
University of Montreal
"Single-Cell RNA Sequencing Analysis of CD8+ T Cell-Mediated Protective Immunity During HCV Reinfection"
Seminar
TWINCORE Seminar
Prof. Heidi Drummer
University of Melbourne, Burnet Institute
"Development of hepatitis C vaccine candidates to generate neutralizing antibodies"
Lecture Series - Regulatory Science and Translational Research - Part 1
"Why is knowledge in regulatory science important for translational medicine and basic science?"
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
