Warm nights and ill premature babies?
A study from Hanover investigates the spread of Klebsiella in the neonatal intensive care unit.
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
TWINCORE Symposium 2026
This year's TWINCORE Symposium will take place on 3 - 4 September.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Plos Pathogens22 (7) : e1014355
Co-regulation of HIV control and cytomegalovirus pp65-specific IL-1β and TNF-α responses by genetic variants in the MHC region
Ruijten S, Dos Santos J, Rios-Vazquez V, Navas A, Maas H, Groenendijk A, Blaauw M, van Eekeren L, Vos W, Knoll R, Kumar Gupta M, Ter Horst R, Botey-Bataller J, van Unen N, Li Y, Aschenbrenner A, Schultze J, Xu C, Netea M, van der Ven A, Matzaraki V
2026Mbio : e0115126
Intra-host viral population dynamics during acute hepatitis E virus infection
Janshoff S, Plümers R, Kohl A, Nocke M, Behrendt P, Knabbe C, Costa R, Vollmer T, Todt D, Steinmann E, Gömer A
2026Plos Neglected Tropical Diseases20 (7) : e0013781
Hantavirus stability and inactivation
Vandenabeele L, Ayanwale A, Pietschmann T, Nilsson-Payant B
Kalinke Lab
Immunology
Regulation of acute hepatitis
The project investigates immune reactions in viral hepatitis, in particular the role of hepatocytes and myeloid cells. The aim is to understand immune processes in the liver and to develop diagnostic approaches for the clinic.
Kalinke Lab
Immunology
Virus control within the CNS
The project investigates the immune response of the central nervous system in viral infections, in particular the role of type I IFN, microglia and monocytes in the development of encephalitis and their influence on seizures and hippocampal damage.
Kalinke Lab
Immunology
Towards the molecular mechanism of HBV vaccination non-responsiveness
The project will investigate the immunological and genetic causes of vaccination failure in 5% of HBV-vaccinated individuals in order to develop new strategies to improve vaccination protection.
Kalinke Lab
Immunology
Cell-selective delivery of active compounds
The project is developing methods to specifically transport antibiotics into cells such as alveolar macrophages, which are important in Mycobacterium tuberculosis infections. The aim is to overcome resistance and reduce side effects.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
