When bacteria remember
New insights into the infection strategy of Pseudomonas aeruginosa
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2025Mabs17 (1) : 2465391
Combinatorial Fc modifications for complementary antibody functionality
Bartsch Y, Webb N, Burgess E, Kang J, Lauffenburger D, Julg B
2025Emerging Microbes & Infections : 2482709
Transmissible Staphylococcus pseudintermedius thwarts neutrophil extracellular trap-driven containment to promote invasive disease
Haller R, Cai Y, DeBuhr N, Rieder J, Schlüter D, Baier C, Rohde H, von Köckritz-Blickwede M, Vital M, Winstel V
2025Hepatology (baltimore, Md.) : 10.1097/HEP.0000000000001340
Reply: Refining epigenetic insights in HBV-Specific T Cell restoration
Chou Y, Cornberg M
Kalinke Lab
Immunology
Virus control within the CNS
The project investigates the immune response of the central nervous system in viral infections, in particular the role of type I IFN, microglia and monocytes in the development of encephalitis and their influence on seizures and hippocampal damage.
Pessler Lab
Immunology
Predictive biomarkers for a poor immune response to influenza vaccination in elderly individuals
Older people are at high risk of a poor immune response to the flu vaccine. Together with partners, we are looking for biomarkers and risk factors for this inadequate response and are investigating ways to improve the vaccination response.
Galardini Lab
Bacteriology
Genotype to phenotype studies in bacteria
By applying statistical genetics methods to pathogen genome sequences, we aim to identify and validate genetic determinants of phenotypes such as pathogenicity, virulence and antibiotic resistance, e.g. in E. coli and P. aeruginosa.
Galardini Lab
Bacteriology
Pangenome wide prediction of gene function
Thanks to high-throughput sequencing, genome sequences of hundreds of bacterial strains can be analyzed efficiently, revealing differences of up to 60 % in gene content, as in E. coli. With the help of machine learning, we want to better predict the functions of accessory genes and decipher their contribution to survival in specialized niches.
There are currently no events.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
