New findings on spinal muscular atrophy
Researchers investigate the impact on the immune system.
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Staying One Step Ahead of Resistance
How bacteria develop resistance to antisense antibiotics - and how future therapies can be designed to reduce the risk of resistance
Antibodies produced following the Ebola vaccination neutralise the current Bundibugyo virus variant
A team of researchers from Hamburg, Berlin, Göttingen and Hannover has provided evidence of possible cross-protection offered by an already authorised Zaire Ebola virus vaccine.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Journal of Controlled Release : Official Journal of the Controlled Release Society : 115509
Overcoming technological and biological barriers to pulmonary mRNA delivery with lipid-polymer hybrid nanoparticles
Biesel A, Shandheep A, Pavlou A, Busker L, Koch M, Kopliku V, Maisel K, Boese A, Skerra J, Schröder L, Neubert L, Schneider-Daum N, Loretz B, Kalinke U, Lehr C
2026European Journal of Immunology56 (10) : e70306
Tolerogenic Programming Promotes Human Cytomegalovirus Permissiveness in Dendritic Cells
Rahmel-Stein K, Becker J, Lange B, Krajewski L, Eiz-Vesper B, Kalinke U
2026Journal of Market Access & Health Policy14 (4) : 61
Improving Patient Access to New Treatment Modalities in European Cancer Care
Schneider C, Morjaria H, Wissink S, Deroose C, Galvao V, Grünwald V, Kiß O, Symeonides S
Graalmann Lab
Immunology
Cell-selective targeting of immune cells
Immunomodulatory drugs can have systemic side effects. This project is testing nanocarriers that deliver drugs specifically into myeloid immune cells in order to reduce side effects and increase the local effect.
Behrendt Lab
Virology
Antiviral Strategies Against HEV
Together with the Department of Structural Biology at the University of Lübeck, human, strongly neutralizing antibodies against HEV were identified and characterized for the first time. These showed a protective effect in the mouse model and are currently being further developed for clinical application, including mRNA-based application methods.
Behrendt Lab
Virology
Determinants of the Clinical Course of Infection
Human, potentially neutralizing antibodies against HEV have advanced the development of new detection methods for the virus in patient samples. Serological and functional analyses are used to determine markers for the course and treatment of chronic infections.
Galardini Lab
Bacteriology
Testing the impact of genetic backgrounds on antimicrobial resistance
Population genetic studies show that genetic variability between bacterial strains can influence the evolution of antimicrobial resistance. Using automated laboratory evolution (ALE), we are investigating how genetic backgrounds control AMR evolution.
There are currently no events.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
