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Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026The Journal of Clinical Investigation136 (4) : e192371
Type I IFN-dependent FcγRIV signaling in murine monocytes promotes lethal anaphylaxis during viral infections
Elwy A, Abdelrahman H, Specht J, Ewert G, Friebus-Kardash J, Dhiman S, Falkenstein J, Christ T, Wiebeck E, Shamoon A, Leimkühler N, Gramberg T, Russ A, Kalinke U, Kuang F, Sutter K, Kopf M, Mack M, Hansen W, Nimmerjahn F, Lang K
2026Nature Communications : 10.1038/s41467-026-69412-1
Opposite effects of chronic HIV infection and antiretroviral medication on organismal and organ-specific biological aging
Zhang Y, Matzaraki V, Vadaq N, Blaauw M, Vos W, Groenendijk A, van Eekeren L, Stalenhoef J, Berrevoets M, Rokx C, Delporte M, Otten T, Joosten L, Xu C, Li Y, Vandekerckhove L, van der Ven A, Netea M
2026Science Immunology11 (116) : eadx8474
Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis
Mayer L, Arnold J, Roettele F, Reuter N, Pattekar A, Ohtani T, Ribeiro M, Siwicki R, Bruder K, Obwegs D, Stahl E, Buechel S, Roehlen N, Kolter J, Mansoori Moghadam Z, Alaswad A, Zhumalidova Z, Li G, Liu X, Li Y, Singh A, Villacorta Hidalgo J, Paraskevopoulou M, Yajnik V, Juarez J, Ren Y, Li H, Wherry E, Lewis J, Wu G, Bewtra M, Tomov V, Thimme R, Bengsch B, Hasselblatt P, Picelli S, Hofmann M, Sagar
Pessler Lab
Immunology
Predictive biomarkers for a poor immune response to influenza vaccination in elderly individuals
Older people are at high risk of a poor immune response to the flu vaccine. Together with partners, we are looking for biomarkers and risk factors for this inadequate response and are investigating ways to improve the vaccination response.
Behrendt Lab
Virology
Antiviral Strategies Against HEV
Together with the Department of Structural Biology at the University of Lübeck, human, strongly neutralizing antibodies against HEV were identified and characterized for the first time. These showed a protective effect in the mouse model and are currently being further developed for clinical application, including mRNA-based application methods.
Galardini Lab
Bacteriology
Testing the impact of genetic backgrounds on antimicrobial resistance
Population genetic studies show that genetic variability between bacterial strains can influence the evolution of antimicrobial resistance. Using automated laboratory evolution (ALE), we are investigating how genetic backgrounds control AMR evolution.
Lauber Lab
Virology
Genetic determinants of severe RSV infection in infants
We are investigating how genetic variants influence the risk of severe RSV infections in infants. Exome sequencing and bioinformatic analyses are used to identify causal variants in immunity genes.
Seminar
TWINCORE Seminar
Prof. Martin Schwemmle, Medical Center University of Freiburg
"Decoding Pandemic Influenza Viruses"
Inaugural Lecture Prof. Marco Galardini
„ Finding the needle in the haystack of microbial pangenomes “
Seminar
TWINCORE Seminar
Prof. Takoto Makeda
Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan
“Host protease-mediated activation of respiratory viruses: From the laboratory bench to the frontlines of infectious disease control”
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
