Optimised active substances against RSV
OPERA research project launched to further develop antiviral active substances
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Lower Saxony International Summer Academy 2026
The LISA Summer School 2026 takes place from 23 August to 11 September 2026. Registration is open until 31 March.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026International Journal of Cancer : 10.1002/ijc.70427
ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance
Sánchez-Maldonado J, Macauda A, Cabrera-Serrano A, Thomsen H, Güler M, Horst R, van Guelpen B, Vodicka P, Landi S, Chattopadhyay S, Ünal P, Ruiz-Durán L, Casabonne D, Goldschmidt H, Serin I, Carretero-Fernández M, Cabezudo E, Reyes-Zurita F, Norman A, García-Sanz R, Capurso G, Hoffmann P, Pettersson-Kymmer U, Jiménez-Romera F, Rajkumar S, Weinhold N, Vodickova L, Langer C, Stein A, Karismaz A, Moreno V, Nöthen M, Jöckel K, Tavano F, Martínez-López J, Kumar S, Gutiérrez-Bautista J, Basso D, Späth F, Benavente Y, Hildebrandt M, Schmidt B, Sevcikova T, Reis R, Li Y, López-Nevot M, Netea M, Campa D, Clay-Gilmour A, Slager S, Hemminki K, Vachon C, Försti A, Canzian F, Sainz J
2026Communications Biology : 10.1038/s42003-026-09724-6
NRF2 activators and the inhibitor of nuclear export, selinexor, restrict coronaviruses by targeting a network involving ACE2, TMPRSS2, and XPO1 through an NRF2-independent mechanism
Waqas F, S da Costa L, Zapatero-Belinchón F, Carter-Timofte M, Lasswitz L, van der Horst D, Möller R, Dahlmann J, Olmer R, Geffers R, Gerold G, Olagnier D, Pessler F
2026The Journal of Clinical Investigation136 (4) : e192371
Type I IFN-dependent FcγRIV signaling in murine monocytes promotes lethal anaphylaxis during viral infections
Elwy A, Abdelrahman H, Specht J, Ewert G, Friebus-Kardash J, Dhiman S, Falkenstein J, Christ T, Wiebeck E, Shamoon A, Leimkühler N, Gramberg T, Russ A, Kalinke U, Kuang F, Sutter K, Kopf M, Mack M, Hansen W, Nimmerjahn F, Lang K
Graalmann Lab
Immunology
Indirect effects of immunomodulatory drugs
Immunomodulatory drugs for rheumatic diseases specifically influence immune cells and messenger substances. This project investigates their effect on immune responses in order to find individually suitable therapies.
Kalinke Lab
Immunology
Regulation of acute hepatitis
The project investigates immune reactions in viral hepatitis, in particular the role of hepatocytes and myeloid cells. The aim is to understand immune processes in the liver and to develop diagnostic approaches for the clinic.
Behrendt Lab
Virology
Prevention of HEV Infection
Studies in the cell culture model show that only a few disinfectants are effective against HEV, which provides important information on hygiene measures for HEV infections. We are also working together to test vaccines for pigs as HEV reservoirs.
Lauber Lab
Virology
Deep exploration of the virosphere for novel viruses in humans and other eukaryotes
Using high-performance computers, we analyze NGS data to discover unknown viruses in the human and animal virome that could influence disease risks. We investigate the virome as a factor for infections and diseases such as cancer and immunodeficiencies.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
