AI in Research and Administration
TWINCORE establishes task force
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Lower Saxony International Summer Academy 2026
The LISA Summer School 2026 takes place from 23 August to 11 September 2026. Registration is open until 31 March.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Hepatology (baltimore, Md.) : 10.1097/HEP.0000000000001769
Two decades of Hepatitis E in solid organ transplantation: From endemic insight to unresolved therapeutic questions
Behrendt P, Neumann-Haefelin C
2026Science Advances12 (14) : eaeb2333
Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt
Prallet S, Maier N, Li A, Afting C, Huang H, Hu J, Toprak E, Keya D, Colasanti O, León-Janampa N, Marlet J, Beisel C, Mogler C, Puchas P, Behrendt P, Boettler T, Steinmann E, Saha S, Laketa V, Lohmann V, Wittbrodt J, Hermann C, Dill M, Dao Thi V
2026Nature Immunology : 10.1038/s41590-026-02472-z
A transcriptomic microglia taxonomy across mouse and human pathologies
Chhatbar C, Sankowski R, Schulz M, Shimizu T, Schwabenland M, Staszewski O, Scheiwe C, Nessler S, Borst K, Dumas A, Trost E, Berchtold D, Brandão W, Mossad O, Dalmau Gasull A, Frosch M, Erny D, Diebold M, Guffart E, Ternka K, Guranda M, Vinnakota J, Friesen M, Ouk K, Waltl I, LaMorte M, Hammond T, Di Liberto G, Vincenti I, Kreutzfeldt M, Mughrabi I, Al-Abed Y, Blank T, Meyer-Luehmann M, Crow Y, Hagen N, Ofengeim D, Zeiser R, Kettwig M, Gärtner J, Meisel A, Schwemmle M, Kalinke U, Beck J, Bengsch B, Thimme R, Butovsky O, Seredenina T, Ransohoff R, Quintana F, Kierdorf K, Merkler D, Stadelmann C, Priller J, Prinz M
Graalmann Lab
Immunology
Cell-selective targeting of immune cells
Immunomodulatory drugs can have systemic side effects. This project is testing nanocarriers that deliver drugs specifically into myeloid immune cells in order to reduce side effects and increase the local effect.
Pessler Lab
Immunology
Cerebrospinal fluid biomarkers for early diagnosis and risk stratification of CNS infections
In collaboration with the Department of Neurology and the Metabolomics Department, the project is investigating metabolic products in cerebrospinal fluid in order to identify biomarkers for CNS infections and cell damage and to distinguish long COVID and viral from autoimmune diseases.
Pietschmann Lab
Virology
Host and viral factors that govern susceptibility to HCV and RSV
We are investigating why HCV infections sometimes heal spontaneously, but often become chronic, and why RSV infections are severe in some children. We use modern sequencing technologies to analyze the genetic characteristics of hosts and pathogens in order to understand susceptibility.
Behrendt Lab
Virology
Determinants of the Clinical Course of Infection
Human, potentially neutralizing antibodies against HEV have advanced the development of new detection methods for the virus in patient samples. Serological and functional analyses are used to determine markers for the course and treatment of chronic infections.
A practical guide to vibe engineering
The seminar covers the principles and tools of "vibe engineering" for using AI coding agents to solve digital problems. Participants will learn how to leverage these agents while understanding and mitigating associated risks to data and intellectual property. The session includes practical examples and guidance for safe implementation.
Lecture Series - Regulatory Science and Translational Research - Part 6
"Challenge Orphan medicines – learnings from the past"
Lecture Series - Regulatory Science and Translational Research - Part 5
"Interaction with regulators, e.g. in preparation of a first clinical study"
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
