AI in Research and Administration
TWINCORE establishes task force
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Lower Saxony International Summer Academy 2026
The LISA Summer School 2026 takes place from 23 August to 11 September 2026. Registration is open until 31 March.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Nature Immunology : 10.1038/s41590-026-02472-z
A transcriptomic microglia taxonomy across mouse and human pathologies
Chhatbar C, Sankowski R, Schulz M, Shimizu T, Schwabenland M, Staszewski O, Scheiwe C, Nessler S, Borst K, Dumas A, Trost E, Berchtold D, Brandão W, Mossad O, Dalmau Gasull A, Frosch M, Erny D, Diebold M, Guffart E, Ternka K, Guranda M, Vinnakota J, Friesen M, Ouk K, Waltl I, LaMorte M, Hammond T, Di Liberto G, Vincenti I, Kreutzfeldt M, Mughrabi I, Al-Abed Y, Blank T, Meyer-Luehmann M, Crow Y, Hagen N, Ofengeim D, Zeiser R, Kettwig M, Gärtner J, Meisel A, Schwemmle M, Kalinke U, Beck J, Bengsch B, Thimme R, Butovsky O, Seredenina T, Ransohoff R, Quintana F, Kierdorf K, Merkler D, Stadelmann C, Priller J, Prinz M
2026Nature Communications : 10.1038/s41467-026-70889-z
Molecular signatures and causal factors underlying latent cytomegalovirus infection among people living with HIV (PLHIV)
Nguyen N, Zhang Z, Jiang X, van Unen N, Dos Santos J, Zhou L, Matzaraki V, Botey-Bataller J, Blaauw M, Vos W, van Eekeren L, Verbon A, Groenendijk A, Stalenhoef J, Berrevoets M, Joosten L, Netea M, Xu C, van der Ven A, Li Y
2026Journal of Clinical Microbiology : e0104425
Genomic epidemiology of Enterococcus faecium bloodstream infections during a VanB-type VRE peak reveals an oligoclonal scenario: an observational study at a German university hospital (2017-2022)
Knegendorf L, Sommer A, Baier C, Weber R, Fischer M, Werner G, Ziesing S, Schlüter D
Graalmann Lab
Immunology
Cell-selective targeting of immune cells
Immunomodulatory drugs can have systemic side effects. This project is testing nanocarriers that deliver drugs specifically into myeloid immune cells in order to reduce side effects and increase the local effect.
Kalinke Lab
Immunology
Towards the molecular mechanism of HBV vaccination non-responsiveness
The project will investigate the immunological and genetic causes of vaccination failure in 5% of HBV-vaccinated individuals in order to develop new strategies to improve vaccination protection.
Pietschmann Lab
Virology
Host and viral factors that govern susceptibility to HCV and RSV
We are investigating why HCV infections sometimes heal spontaneously, but often become chronic, and why RSV infections are severe in some children. We use modern sequencing technologies to analyze the genetic characteristics of hosts and pathogens in order to understand susceptibility.
Galardini Lab
Bacteriology
Pangenome wide prediction of gene function
Thanks to high-throughput sequencing, genome sequences of hundreds of bacterial strains can be analyzed efficiently, revealing differences of up to 60 % in gene content, as in E. coli. With the help of machine learning, we want to better predict the functions of accessory genes and decipher their contribution to survival in specialized niches.
Seminar
TWINCORE Seminar
Prof. Dr. Niels Lemmermann
Institut für Virologie
Universitätsklinikum Bonn
“From Virus to T Cells: Antigen Presentation During mCMV Infection”
Lecture Series - Regulatory Science and Translational Research - Part 5
"Interaction with regulators, e.g. in preparation of a first clinical study"
A practical guide to vibe engineering
The seminar covers the principles and tools of "vibe engineering" for using AI coding agents to solve digital problems. Participants will learn how to leverage these agents while understanding and mitigating associated risks to data and intellectual property. The session includes practical examples and guidance for safe implementation.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
