New findings on spinal muscular atrophy
Researchers investigate the impact on the immune system.
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Staying One Step Ahead of Resistance
How bacteria develop resistance to antisense antibiotics - and how future therapies can be designed to reduce the risk of resistance
Antibodies produced following the Ebola vaccination neutralise the current Bundibugyo virus variant
A team of researchers from Hamburg, Berlin, Göttingen and Hannover has provided evidence of possible cross-protection offered by an already authorised Zaire Ebola virus vaccine.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Proceedings of the National Academy of Sciences of the United States of America123 (40) : e2615985123
Dynamic tRNA modification programs align codon usage with growth-phase-specific gene expression in Pseudomonas aeruginosa
Frommeyer Y, Sun J, Wu J, Kennepohl B, Witte J, Gomez N, Battermann J, Becker L, Cetraro P, Verstraten R, Tomasch J, Pich A, Depledge D, Dedon P, Häussler S
2026Mbio : e0155126
Role of O-specific antigen expression in Pseudomonas aeruginosa pathogenicity
Hartmann O, Preusse M, Heroven A, Felgner S, Gür M, Kordes A, Wolff Bengtsen V, Roghanian M, Zhao X, Müsken M, Gomez N, Häussler S
2026Respiratory Research27 (1) : 374
The Tie-2 agonist PMC-403 inhibits endothelial damage induced by e-cigarette vapor or LPS
Pape T, Pak O, Graalmann T, Ehlers C, Deutscher J, Spiegelberg D, Horn P, Stahl K, Hoeper M, David S, Sommer N, Seeliger B
Graalmann Lab
Immunology
Cell-selective targeting of immune cells
Immunomodulatory drugs can have systemic side effects. This project is testing nanocarriers that deliver drugs specifically into myeloid immune cells in order to reduce side effects and increase the local effect.
Bartsch Lab
Immunology
Protective anti-viral immunity – learning from natural examples
In this project, antibodies that help to ward off infections are being investigated in more detail. The aim is to find characteristics that have a protective effect against certain pathogens by comparing different antibody profiles in infections and vaccinations.
Lauber Lab
Virology
Deep exploration of the virosphere for novel viruses in humans and other eukaryotes
Using high-performance computers, we analyze NGS data to discover unknown viruses in the human and animal virome that could influence disease risks. We investigate the virome as a factor for infections and diseases such as cancer and immunodeficiencies.
Galardini Lab
Bacteriology
Testing the impact of genetic backgrounds on antimicrobial resistance
Population genetic studies show that genetic variability between bacterial strains can influence the evolution of antimicrobial resistance. Using automated laboratory evolution (ALE), we are investigating how genetic backgrounds control AMR evolution.
Seminar
TWINCORE Seminar - Systems Immunology
Dr. Verónica Durán
Stanford University School of Medicine, Stanford
"Age-dependent immune landscape in dengue infection and disease progression"
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Prof. Shirit Einav
Stanford University School of Medicine, Stanford
"Targeting an understudied lipid kinase to restore lysosomal function in viral infection and neurodegeneration"
Lecture Series - Regulatory Science and Translational Research - Part 1
"Why is knowledge in regulatory science important for translational medicine and basic science?"
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
