Warm nights and ill premature babies?
A study from Hanover investigates the spread of Klebsiella in the neonatal intensive care unit.
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
TWINCORE Symposium 2026
This year's TWINCORE Symposium
Pathways to infection resilience
will take place on 3 - 4 September.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Nature Communications17 (1) : 7266
JN.1-adapted vaccination is associated with readjustment of ancestral memory B cells toward neutralization within the JN.1 antigenic space
Stankov M, Bruhn M, Hoffmann M, Salam A, Eichmann A, Nehlmeier I, Manthey L, Witte T, Pöhlmann S, Ahrenstorf G, Happle C, Dopfer-Jablonka A, Kalinke U, Behrens G
2026Interdisciplinary Sciences, Computational Life Sciences : 10.1007/s12539-026-00855-2
Integrated Genome-Wide Association Study and Machine Learning Approach for Characterizing the Determinants of Biofilm Formation in Staphylococcus aureus
Sidarous L, Ibrahim M, Elhadidy M, Abouelfetouh A, Saif N, Aboelnaga N, Shehat M, Youssef M, Badr E
2026Immunity & Ageing : I & a23 (1) : 24
Reduced NK cell frequency in older patients with evolving fractures is linked to a distinct inflammatory cytokine profile
Moch J, Kappes J, Jauregui R, Schmaus H, Dietrich M, Thies D, Roesner L, Werfel T, Förster R, von Witzendorff D, Debarry J, Winkelmann M, Oberthür S, Clausen J, Gogol M, Cornberg M, Kraft A, Niehaus C
Pessler Lab
Immunology
Functional Biomarkers for respiratory infections
This project focuses on lung infections such as influenza, COVID-19, pneumonia and tuberculosis in order to improve diagnostics, patient stratification and therapy. RNA molecules and metabolites are being investigated as biomarkers and complementary therapies.
Pietschmann Lab
Virology
Host and viral factors that govern susceptibility to HCV and RSV
We are investigating why HCV infections sometimes heal spontaneously, but often become chronic, and why RSV infections are severe in some children. We use modern sequencing technologies to analyze the genetic characteristics of hosts and pathogens in order to understand susceptibility.
Behrendt Lab
Virology
Determinants of the Clinical Course of Infection
Human, potentially neutralizing antibodies against HEV have advanced the development of new detection methods for the virus in patient samples. Serological and functional analyses are used to determine markers for the course and treatment of chronic infections.
Behrendt Lab
Virology
Prevention of HEV Infection
Studies in the cell culture model show that only a few disinfectants are effective against HEV, which provides important information on hygiene measures for HEV infections. We are also working together to test vaccines for pigs as HEV reservoirs.
Science and Society
Science and Society
Ralf Meister, Bishop of the Evangelical-Lutheran Church of Hanover
“Participation and Resilience at the Interface between Science and Society”
Symposium
TWINCORE & CiiM Symposium 2026
Pathways to Infection Resilience
Lecture Series - Regulatory Science and Translational Research - Part 1
"Why is knowledge in regulatory science important for translational medicine and basic science?"
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
