Warm nights and ill premature babies?
A study from Hanover investigates the spread of Klebsiella in the neonatal intensive care unit.
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
TWINCORE Symposium 2026
This year's TWINCORE Symposium
Pathways to infection resilience
will take place on 3 - 4 September.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Nature Communications17 (1) : 7266
JN.1-adapted vaccination is associated with readjustment of ancestral memory B cells toward neutralization within the JN.1 antigenic space
Stankov M, Bruhn M, Hoffmann M, Salam A, Eichmann A, Nehlmeier I, Manthey L, Witte T, Pöhlmann S, Ahrenstorf G, Happle C, Dopfer-Jablonka A, Kalinke U, Behrens G
2026Interdisciplinary Sciences, Computational Life Sciences : 10.1007/s12539-026-00855-2
Integrated Genome-Wide Association Study and Machine Learning Approach for Characterizing the Determinants of Biofilm Formation in Staphylococcus aureus
Sidarous L, Ibrahim M, Elhadidy M, Abouelfetouh A, Saif N, Aboelnaga N, Shehat M, Youssef M, Badr E
2026Immunity & Ageing : I & a23 (1) : 24
Reduced NK cell frequency in older patients with evolving fractures is linked to a distinct inflammatory cytokine profile
Moch J, Kappes J, Jauregui R, Schmaus H, Dietrich M, Thies D, Roesner L, Werfel T, Förster R, von Witzendorff D, Debarry J, Winkelmann M, Oberthür S, Clausen J, Gogol M, Cornberg M, Kraft A, Niehaus C
Kalinke Lab
Immunology
Cell-selective delivery of active compounds
The project is developing methods to specifically transport antibiotics into cells such as alveolar macrophages, which are important in Mycobacterium tuberculosis infections. The aim is to overcome resistance and reduce side effects.
Kalinke Lab
Immunology
Towards the development of novel cell therapy options for MSMD patients
The project is developing iPSC-based therapies for MSMD patients, a genetic disease with mutations in the IFN-γ signaling pathway that lead to severe mycobacterial infections. The aim is to improve the treatment prognosis.
Pietschmann Lab
Virology
Antiviral agents against HCV, RSV and coronavirus
We develop high-throughput screening assays to identify antiviral molecules against RSV and SARS-CoV-2. We use compound libraries, investigate new mechanisms of action and strive for innovative therapies.
Behrendt Lab
Virology
Determinants of the Clinical Course of Infection
Human, potentially neutralizing antibodies against HEV have advanced the development of new detection methods for the virus in patient samples. Serological and functional analyses are used to determine markers for the course and treatment of chronic infections.
Science and Society
Science and Society
Ralf Meister, Bishop of the Evangelical-Lutheran Church of Hanover
“Participation and Resilience at the Interface between Science and Society”
LISA Summer Academy Key Note Lecture
Moritz Gaidt, IMP - Research Institute of Molecular Pathology, Vienna
LISA Summer Academy Key Note Lecture
Marylyn M. Addo - UKE Hamburg
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
