
Better fight against hepatitis E
Neutralising antibodies can prevent severe courses
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
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We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
Bartsch Y, Webb N, Burgess E, Kang J, Lauffenburger D, Julg B
van der Sluis R, García-Rodríguez J, Nielsen I, Gris-Oliver A, Becker J, Costa B, Chaudhry M, Werner M, Laustsen A, Pedersen J, Gammelgaard K, Mogensen T, Kalinke U, Cicin-Sain L, Bak R, Kristensen L, Jakobsen M
Goranovič D, Jenko B, Ramšak B, Podgoršek Berke A, Bedrač L, Horvat J, Šala M, Makuc D, Carriche G, Silva L, Lopez Krol A, Pšeničnik A, Durán Alonso M, Avbelj M, Stavber S, Plavec J, Sparwasser T, Müller R, Kosec G, Fujs Š, Petković H
Immunomodulatory drugs for rheumatic diseases specifically influence immune cells and messenger substances. This project investigates their effect on immune responses in order to find individually suitable therapies.
The project is developing methods to specifically transport antibiotics into cells such as alveolar macrophages, which are important in Mycobacterium tuberculosis infections. The aim is to overcome resistance and reduce side effects.
We are investigating how the association of HCV with lipoproteins contributes to the persistence of the virus by influencing entry into liver cells and protecting against antibodies. The aim is to gain new insights for the development of an HCV vaccine.
We are investigating how antibodies protect against HCV infection, in particular what properties they have during a healing infection. The aim is to identify antibodies that are important for an effective vaccine against HCV.