Immunology

Kalinke Lab

Ulrich Kalinke

Head

Prof. Dr. Ulrich Kalinke

Publications

2025Arthritis & Rheumatology (hoboken, N.j.)77 (1) : 59-66

Toll-Like Receptor 8 is Expressed in Monocytes in Contrast to Plasmacytoid Dendritic Cells and Mediates Aberrant Interleukin-10 Responses in Patients With Systemic Sclerosis

Ehlers C, Thiele T, Biermann H, Traidl S, Bruns L, Ziegler A, Schefzyk M, Bartsch L, Kalinke U, Witte T, Graalmann T

2024Neurobiology of Disease205 : 106773

Alpha-synuclein pathology enhances peripheral and CNS immune responses to bacterial endotoxins

Hartke A, Schreiber C, Lau K, Wiesweg I, Waltl I, Kalinke U, Richter F, Käufer C

2024Gene927 : 148649

Birch pollen-induced signatures in dendritic cells are maintained upon additional cytomegalovirus exposure

Fneish Z, Becker J, Mulenge F, Fneish F, Costa B, Traidl-Hoffmann C, Gilles S, Kalinke U

2024Journal of Neuroinflammation21 (1) : 264

MAVS signaling shapes microglia responses to neurotropic virus infection

Gern O, Pavlou A, Mulenge F, Busker L, Ghita L, Aringo A, Costa B, Spanier J, Waltl I, Stangel M, Kalinke U

2024Plos Pathogens20 (9) : e1012569

Multifaceted activation of STING axis upon Nipah and measles virus-induced syncytia formation

Amurri L, Dumont C, Pelissier R, Reynard O, Mathieu C, Spanier J, Pályi B, Déri D, Karkowski L, Gonzalez C, Skerra J, Kis Z, Kalinke U, Horvat B, Iampietro M

2024Cellular & Molecular Immunology21 (9) : 943-958

Orchestration of antiviral responses within the infected central nervous system

Pavlou A, Mulenge F, Gern O, Busker L, Greimel E, Waltl I, Kalinke U

2024Genome Biology25 (1) : 228

Real-time identification of epistatic interactions in SARS-CoV-2 from large genome collections

Innocenti G, Obara M, Costa B, Jacobsen H, Katzmarzyk M, Cicin-Sain L, Kalinke U, Galardini M

2024Journal of Neuroinflammation21 (1) : 203

Transcriptomic analysis unveils bona fide molecular signatures of microglia under conditions of homeostasis and viral encephalitis

Mulenge F, Gern O, Busker L, Aringo A, Ghita L, Waltl I, Pavlou A, Kalinke U

2024Allergy : 10.1111/all.16241

Anti-TNF therapy impairs both short- and long-term IgG responses after repeated vaccination

Buhre J, Pongracz T, Geisen U, Schubert M, Wang W, Nouta J, Obara M, Lehrian S, Rahmöller J, Petry J, Tran F, Schreiber S, Sümbül M, Berner D, Gerdes S, Schirmer J, Longardt A, Hoff P, Kalinke U, Ludwig R, Bartsch Y, Hoyer B, Wuhrer M, Ehlers M

2024Vaccines12 (7) : 791

Construction and Characterization of a High-Capacity Replication-Competent Murine Cytomegalovirus Vector for Gene Delivery

Riedl A, Bojková D, Tan J, Jeney Á, Larsen P, Jeney C, Full F, Kalinke U, Ruzsics Z

Posts

Dr. Matthias Bruhn and Prof. Ulrich Kalinke

Dr Matthias Bruhn awarded doctoral prize by the HZI Förderverein

Award ceremony as part of the Inhoffen Lecture on 13 June 2024

Photo of Dr. Bibiana Costa and Prof. Ulrich Kalinke

Doctoral Prize of the Friends of the MHH goes to Dr Bibiana Costa

TWINCORE scientist honoured for outstanding doctoral thesis.

17 December 2013 Trojan horse for the treatment of tuberculosis

25 September 2013 HAI at TWINCORE

Forschen zwischen Grundlagen und Zulassung - Neue Forschungsrichtung am TWINCORE

The GO-Bio initial applicant Matthias Bruhn (m.) with his supporters Elisabeth Janecek-Erfurth and Ulrich Kalinke.

Start-up funding for antibody project

MEMUMAB research project receives GO-Bio initial funding / Kickoff on 22 November

Christine Ehlers and Theresa Graalmann in the lab

New approaches to research into systemic sclerosis

A research team at TWINCORE was able to establish that TLR8 influences the formation of disease-relevant cytokines.

Marco Galardini and Maureen Obara in the lab

More than the sum of the parts

TWINCORE researchers show role of epistatic interaction in the omicron variant of SARS-CoV-2 virus .

The scientist Dr Matt Matthias Bruhn is sitting at a sterile bench in the laboratory.

Diversity is the key

How B cells recognise new variants of SARS-CoV-2

Scientist Bibiana Costa in a lab.

Hijacking in the immune system

HCMV reprograms cellular defence mechanisms

Zeinab Fneish (l.) and Dr. Jennifer Becker analysed the influence of birch pollen on the susceptibility to infections.

How pollen increases susceptibility to virus infection

TWINCORE researchers describe how birch pollen affects immune cells

Theresa Graalmann at the microscope

Vaccination success without B cells

Communication between immune cells determines response to vaccination

A call for help from the brain

How immune cells are lured to the brain in encephalitis

A Trojan horse against tuberculosis

New transport route for antibiotics directly into infected cells

How cytomegaloviruses are kept in check

Important mechanism of antigen presentation in guard cells of the immune system riddled

New inhibition mechanism for Human Cytomegalovirus

Does the liver fend heard muscle inflammation caused by Coxsackieviruses?

Hepatitis therapy: balance between defence and regeneration via Kupffer cells

Virus infections of bone marrow donors influence the outcome of transplantations

New perspectives for research on hepatitis C virus

Mode of action of a novel RNA-adjuvants detected – successful collaboration with the CureVac AG

TWINCORE scientists identified cause of susceptibility to infection in rheumatism patients

Cytomegalie research with human cells - on the trail of HCMV

Olfactory bulbs as a branch of the immune system - the olfactory brain defends independently against viruses

A direct view into the "control center" of the immune system

Magic cap lifted

TWINCORE scientists decode a new camouflage mechanism of cytomegalovirus

3 September 2014 Mechanisms of interferon production explored - New perspectives for the defense against serious infectious diseases

Where does the interferon for the early virus defence come from?

7 February 2014 Antibodies as drugs - New prediction systems for the reaction in humans

10 October 2013 Admission requirements for individual cancer therapies published in Nature Biotech

28 September 10 Neuer Mechanismus bei der Virenabwehr entdeckt: Interferon macht das spezifische Immunsystem gegen Viren mobil

Researcher Dr. Felix Mulenge in front of a computer

Better results through less stress

Researchers in Hannover have developed a new method for studying neuroinfections.

Portrait of Dr. Dr. Theresa Graalmann in the garden of TWINCORE

New junior research group "Translational Immunology

Clinician scientist Theresa Graalmann starts her own group at TWINCORE

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