Transcriptomic analysis unveils bona fide molecular signatures of microglia under conditions of homeostasis and viral encephalitis
Mulenge F, Gern O, Busker L, Aringo A, Ghita L, Waltl I, Pavlou A, Kalinke U
Prof. Dr. Ulrich Kalinke is Managing Director of TWINCORE, Center for Experimental and Clinical Infection Research, where he also heads the Institute for Experimental Infection Research. After studying biology in Hanover, he completed his doctorate at the German Cancer Research Center in Heidelberg. Here he investigated peripheral T cell tolerance and the role of CD8 as a co-receptor in specific T cell recognition. Kalinke spent his postdoctoral period in Zurich, Switzerland, where he worked in the laboratory of Nobel Prize winner Rolf Zinkernagel. During this time, he analysed virus-neutralizing antibody reactions. He then spent four years conducting research at the European Molecular Biology Laboratory in Monterotondo (Italy). In this environment, he focused on the analysis of the innate immune response to viral infections. In 2002, he was appointed Professor and Head of the Department of Immunology at the Paul Ehrlich Institute in Langen. There he was responsible for all aspects of licensing monoclonal and polyclonal antibodies and therapeutic vaccines. In addition, he conducted basic research to better understand the interface between innate and adaptive immunity. During this time, Kalinke became involved in regulatory research, where he and his colleagues tackled topics such as the opportunities and challenges of biosimilar monoclonal antibodies and new developments in tumor vaccines. In his current position, he is developing a translational infection research program as a joint venture between the Helmholtz Centre for Infection Research in Braunschweig and the Hannover Medical School. Since 2013, he has headed the office of the Translational Alliance in Lower Saxony (TRAIN), which aims to (i) improve the research infrastructure, (ii) develop new teaching formats for postgraduates and (iii) establish TRAIN projects in the Hannover-Braunschweig region.
The project investigates immune reactions in viral hepatitis, in particular the role of hepatocytes and myeloid cells. The aim is to understand immune processes in the liver and to develop diagnostic approaches for the clinic.
The project investigates the immune response of the central nervous system in viral infections, in particular the role of type I IFN, microglia and monocytes in the development of encephalitis and their influence on seizures and hippocampal damage.
The project will investigate the immunological and genetic causes of vaccination failure in 5% of HBV-vaccinated individuals in order to develop new strategies to improve vaccination protection.
The project is developing iPSC-based therapies for MSMD patients, a genetic disease with mutations in the IFN-γ signaling pathway that lead to severe mycobacterial infections. The aim is to improve the treatment prognosis.
Mulenge F, Gern O, Busker L, Aringo A, Ghita L, Waltl I, Pavlou A, Kalinke U
Innocenti G, Obara M, Costa B, Jacobsen H, Katzmarzyk M, Cicin-Sain L, Kalinke U, Galardini M
Pavlou A, Mulenge F, Gern O, Busker L, Greimel E, Waltl I, Kalinke U
Award ceremony as part of the Inhoffen Lecture on 13 June 2024
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