2026Hepatology (baltimore, Md.) : 10.1097/HEP.0000000000001769
Two decades of Hepatitis E in solid organ transplantation: From endemic insight to unresolved therapeutic questions
Behrendt P, Neumann-Haefelin C
Dr. Patrick Behrendt
Group Leader
About
Patrick Behrendt has been leading the Junior Research Group for Translational Virology as part of the Institute for Experimental Virology at TWINCORE in Hannover since 2019. From 2011 to 2019, he worked as a physician scientist at the Institute for Experimental Virology at TWINCORE. Since 2022, Patrick Behrendt has been a senior physician and head of the Ultrasound Unit in the Department of Gastroenterology, Hepatology, Infectiology, and Endocrinology at Hannover Medical School, where he has also been working as a physician since 2010. In 2022, he specialized in General Internal Medicine. Patrick Behrendt completed his doctoral thesis from 2008 to 2010 under the supervision of Prof. Heike Kielstein at the Institute of Pathology at Hannover Medical School. From 2003 to 2009, he studied Human Medicine at Hannover Medical School.
Research Lab
Participation in other Research Labs
Projects
Behrendt Lab
Virology
Antiviral Strategies Against HEV
Together with the Department of Structural Biology at the University of Lübeck, human, strongly neutralizing antibodies against HEV were identified and characterized for the first time. These showed a protective effect in the mouse model and are currently being further developed for clinical application, including mRNA-based application methods.
Behrendt Lab
Virology
Determinants of the Clinical Course of Infection
Human, potentially neutralizing antibodies against HEV have advanced the development of new detection methods for the virus in patient samples. Serological and functional analyses are used to determine markers for the course and treatment of chronic infections.
Behrendt Lab
Virology
Prevention of HEV Infection
Studies in the cell culture model show that only a few disinfectants are effective against HEV, which provides important information on hygiene measures for HEV infections. We are also working together to test vaccines for pigs as HEV reservoirs.
Kalinke Lab
Bartsch Lab
Behrendt Lab
Pietschmann Lab
Immunology
Platform for the rapid development of new pathogen-directed humanized or fully human monoclonal antibody candidates (MEMUMAB)
Monoclonal antibodies are transforming modern medicine. At Helmholtz Infection Medicine at MHH, bringing together TWINCORE and CiiM, advanced technologies and AI drive the development of next-generation human antibodies against major infectious diseases.
Publications
2026Science Advances12 (14) : eaeb2333
Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt
Prallet S, Maier N, Li A, Afting C, Huang H, Hu J, Toprak E, Keya D, Colasanti O, León-Janampa N, Marlet J, Beisel C, Mogler C, Puchas P, Behrendt P, Boettler T, Steinmann E, Saha S, Laketa V, Lohmann V, Wittbrodt J, Hermann C, Dill M, Dao Thi V
2025Liver International : Official Journal of the International Association for the Study of the Liver45 (9) : e70246
Design and Analysis of Novel HEV Vaccine Variants and Evaluation of Two Selected Candidates in a Porcine Infection Model
Hrabal I, Aliabadi E, Weber S, Ssebyatika G, Krey T, Holicki C, Schmid L, Dinkelborg K, Schröder C, Fast C, Behrendt P, Groschup M, Eiden M
2025Liver International : Official Journal of the International Association for the Study of the Liver45 (7) : e70183
Extrahepatic Replication and Genomic Signatures of the Hepatitis E Virus in the Kidney
Wahid A, Meyer N, Wundes C, Hüffner L, Janshoff S, Frericks N, Friesland M, Dinkelborg K, Aliabadi E, Laue F, Cornberg M, Maasoumy B, Bremer B, Pischke S, Müller T, Wiesch J, Benckert J, Ulrich R, Hardtke S, Dörge P, Vondran F, Lohse A, Manns M, Todt D, Wedemeyer H, Pietschmann T, Steinmann E, Gömer A, Behrendt P
2025Scientific Reports15 (1) : 17845
Correction: Therapeutic treatment of hepatitis E virus infection in pigs with a neutralizing monoclonal antibody
Hrabal I, Aliabadi E, Reiche S, Weber S, Holicki C, Schmid L, Fast C, Schröder C, Gutjahr B, Behrendt P, Groschup M, Eiden M
Posts
Virus on the loose
Research team from Bochum and Hannover shows that the hepatitis E virus also attacks organs other than the liver
TWINCORE team participates in Hannover Marathon
Relay team comes in at rank 536
Better fight against hepatitis E
Neutralising antibodies can prevent severe courses