Virology

Pietschmann Lab

Thomas Pietschmann
Head

Prof. Thomas Pietschmann


2025International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases : 107802

Acute respiratory tract infections during the first six years of life - results from the German birth cohort study LoewenKIDS

Klee B, Diexer S, Langer S, Gottschick C, Hartmann C, Glaser N, Horn J, Dorendorf E, Raupach-Rosin H, Hassan L, Rübsamen N, Meyer-Schlinkmann K, Guzman C, Heselich V, Battin E, Pietschmann T, Pieper D, Pletz M, Riese P, Trittel S, Thies S, von Kaisenberg C, Dressler F, Guthmann F, Oberhoff C, Schild R, Karch A, Mikolajczyk R

2025Chemistry (Weinheim an der Bergstrasse, Germany)31 (4) : e202403390

Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potential Against SARS-CoV-2

Jumde R, Jézéquel G, Saramago M, Frank N, Adam S, Cunha M, Bader C, Gunesch A, Köhler N, Johannsen S, Bousis S, Pietschmann T, Matos R, Müller R, Arraiano C, Hirsch A

2024Science advances10 (49) : eado2600

Epitope-focused immunogens targeting the hepatitis C virus glycoproteins induce broadly neutralizing antibodies

Nagarathinam K, Scheck A, Labuhn M, Ströh L, Herold E, Veselkova B, Tune S, Cramer J, Rosset S, Vollers S, Bankwitz D, Ballmaier M, Böning H, Roth E, Khera T, Ahsendorf-Abidi H, Dittrich-Breiholz O, Obleser J, Nassal M, Jäck H, Pietschmann T, Correia B, Krey T

2024Frontiers in immunology15 : 1443665

A clinical protocol for a German birth cohort study of the Maturation of Immunity Against respiratory viral Infections (MIAI)

Hartmann C, Khan R, Schöning J, Richter M, Willers M, Pirr S, Heckmann J, Dirks J, Morbach H, Konrad M, Fries E, Winkler M, Büchel J, Seidenspinner S, Fischer J, Vollmuth C, Meinhardt M, Marissen J, Schmolke M, Haid S, Pietschmann T, Backes S, Dölken L, Löber U, Keil T, Heuschmann P, Wöckel A, Sagar, Ulas T, Forslund-Startceva S, Härtel C, Viemann D

2024PLoS pathogens20 (9) : e1012509

The triglyceride-synthesizing enzyme diacylglycerol acyltransferase 2 modulates the formation of the hepatitis C virus replication organelle

Reichert I, Lee J, Weber L, Fuh M, Schlaeger L, Rößler S, Kinast V, Schlienkamp S, Conradi J, Vondran F, Pfaender S, Scaturro P, Steinmann E, Bartenschlager R, Pietschmann T, Heeren J, Lauber C, Vieyres G

2024PLoS pathogens20 (4) : e1012163

Deep mining of the Sequence Read Archive reveals major genetic innovations in coronaviruses and other nidoviruses of aquatic vertebrates

Lauber C, Zhang X, Vaas J, Klingler F, Mutz P, Dubin A, Pietschmann T, Roth O, Neuman B, Gorbalenya A, Bartenschlager R, Seitz S

2024Infection52 (2) : 513-524

Blood T cell phenotypes correlate with fatigue severity in post-acute sequelae of COVID-19

Pink I, Hennigs J, Ruhl L, Sauer A, Boblitz L, Huwe M, Fuge J, Falk C, Pietschmann T, de Zwaan M, Prasse A, Kluge S, Klose H, Hoeper M, Welte T

2024Journal of virology98 (3) : e0192123

Unraveling the dynamics of hepatitis C virus adaptive mutations and their impact on antiviral responses in primary human hepatocytes

Frericks N, Brown R, Reinecke B, Herrmann M, Brüggemann Y, Todt D, Miskey C, Vondran F, Steinmann E, Pietschmann T, Sheldon J

2024Antimicrobial agents and chemotherapy68 (3) : e0121023

Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets

Haid S, Matthaei A, Winkler M, Sake S, Gunesch A, Milke V, Köhler N, Rückert J, Vieyres G, Kühl D, Nguyen T, Göhl M, Lasswitz L, Zapatero-Belinchón F, Brogden G, Gerold G, Wiegmann B, Bilitewski U, Brown R, Brönstrup M, Schulz T, Pietschmann T

2024Nature communications15 (1) : 1173

Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor

Sake S, Zhang X, Rajak M, Urbanek-Quaing M, Carpentier A, Gunesch A, Grethe C, Matthaei A, Rückert J, Galloux M, Larcher T, Le Goffic R, Hontonnou F, Chatterjee A, Johnson K, Morwood K, Rox K, Elgaher W, Huang J, Wetzke M, Hansen G, Fischer N, Eléouët J, Rameix-Welti M, Hirsch A, Herold E, Empting M, Lauber C, Schulz T, Krey T, Haid S, Pietschmann T


Posts

TWINCORE researcher Dr. Julie Sheldon in the laboratory next to a digital microscope

A major step for HCV research

Research team from Hannover adapts hepatitis C virus to infect mouse liver cells

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New research group “Computational Virology” at TWINCORE

Group leader Chris Lauber funded by RESIST 

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Searching for drugs against SARS-CoV-2

RESIST-Scientist Professor Pietschmann, head of the TWINCORE Insitute for Experimental Virology, leads the German part of an international consortium of scientists. This research network is searching for substances that act against SARS-CoV-2 in the world's largest substance repurposing bank "ReFrame".

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25 September 2013 HAI at TWINCORE

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20. August 2013 Becton-Dickinson Biosciences PhD prize for Kathrin Hüging

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5 July 2013 Specific characteristics of hepatitis C virus - a first step towards individualized HCV therapy

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Photo of the current five-member DZIF Executive Board and the management

Thomas Pietschmann elected to the Executive Board of the DZIF

DZIF Press Release

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Microtiter plates with virological tests

Volkswagen Stiftung funds research on antiviral agents

Team led by TWINCORE virologist Pietschmann receives around 700,000 euros for RSV project 

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Microscopic image of cells transfected with RSV. Green: RSV-F protein labelled with GFP in the cytoplasm of the cells, magenta: RSV-F protein, blue: cell nuclei. ©TWINCORE/Carpentier

New hope in the fight against RSV

TWINCORE researchers discover promising drug candidate 

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Lung cell infected with SARS-CoV-2 forms new virus particles (green) in its cytoplasm (violet: cell nuclei). ©HZI/Ulfert Rand

Bacterial weapons against viral diseases

Discovery of two novel classes of natural products with activity against RNA viruses 

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Lipid-lowering drugs not a risk factor in COVID-19.

Statins do not increase infectivity or viral replication of SARS-CoV-2

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A precise measure of protective immunity

New tool aims to make HCV vaccine search easier

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Two murine restriction factors limiting hepatitis C infection described

Research team at TWINCORE, with international collaborators, clarifies why mice are not susceptible to infection with hepatitis C virus 

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Eliminating hepatitis C viruses effectively

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Protein complex for hepatitis C-virus entry in liver cells is characterised

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New treatment approach for hepatitis E infections in pregnant women

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New perspectives for research on hepatitis C virus

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WHO handrub formulations are effective against emerging viruses

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Combined strength – immune cells cooperate in HIV defence

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Hepatitis C virus hijacks the host's fat metabolism

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Migränetabletten gegen Hepatitis C – Flunarizin hemmt den Viruseintritt in die Leberzellen

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Neuer antiviraler Mechanismus gegen Hepatitis C-Viren entdeckt

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Bionorica Phytoneering Award 2015 for Eike Steinmann and Anggakusuma

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Snapshot of a hepatitis C virus attack - new analysis method deciphers the molecular mechanism of infection

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Doctoral award of the MHH for Anggakusuma

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27 October 2014 Virologists want to learn from horses: horses sucessfully fend off the non-primate hepacivirus

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28 October 2013 As strong as a disinfectant: breast milk inactivates hepatitis C viruses

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27 August 2013 Kitchen spice against hepatitis-C - curcumin from turmeric spice prevents hepatitis C viruses to enter liver cells

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7 November 2012 Hepatitis C virus infections in the drug scene - The transmission pathways of the virus

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30 July 2012 Neues Schlüsselenzym für die Virusvermehrung entdeckt

Wissenschaftler des TWINCORE stören die Infektionskette des Hepatitis-C-Virus

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12 June 2012 Neuer Forschungsschwerpunkt am TWINCORE - Institut für Experimentelle Virologie erforscht RNA-Viren

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23 April 2012 Ein neuer Naturstoff schützt vor Infektionen mit dem Hepatitis-C-Virus

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4 November 2011 ERC Starting Grant for Thomas Pietschmann

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Hepatitis C am Scheideweg: Forscher am TWINCORE suchen einen Weg zu neuen Forschungsmodellen für HCV

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5 July 10 A new opportunity for hepatitis C research

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