Virology

Pietschmann Lab

Thomas Pietschmann
Head

Prof. Thomas Pietschmann

Pietschmann Lab
Virology

Principles of HCV assembly and entry and their role in virus persistence

We are investigating how the association of HCV with lipoproteins contributes to the persistence of the virus by influencing entry into liver cells and protecting against antibodies. The aim is to gain new insights for the development of an HCV vaccine.

Pietschmann Lab
Virology

Determinants of protective immunity in HCV: A gold standard for vaccine development

We are investigating how antibodies protect against HCV infection, in particular what properties they have during a healing infection. The aim is to identify antibodies that are important for an effective vaccine against HCV.

Pietschmann Lab
Virology

Mechanisms of HCV tissue and species tropism: A guide for development of animal models

The project investigates the factors that determine the species barrier mechanism of HCV and make it impossible to study the infection in animal models. The aim is to use genetic screening systems to develop in vivo models for vaccine research.

Pietschmann Lab
Virology

Antiviral agents against HCV, RSV and coronavirus

We develop high-throughput screening assays to identify antiviral molecules against RSV and SARS-CoV-2. We use compound libraries, investigate new mechanisms of action and strive for innovative therapies.

Pietschmann Lab
Virology

Host and viral factors that govern susceptibility to HCV and RSV

We are investigating why HCV infections sometimes heal spontaneously, but often become chronic, and why RSV infections are severe in some children. We use modern sequencing technologies to analyze the genetic characteristics of hosts and pathogens in order to understand susceptibility.

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