Immunology

Pessler Lab

Head

Prof. Dr. Frank Pessler

Publications

2024Pathogens (Basel, Switzerland)13 (12) : 1082

Vaccination Schedule and Age Influence Impaired Responsiveness to Hepatitis B Vaccination: A Randomized Trial in Central Asia

Heisig J, Nurmatov Z, Riese P, Trittel S, Sattarova G, Temirbekova S, Zhumagulova G, Nuridinova Z, Derkenbaeva A, Arykbaeva B, Dzhangaziev B, Prokein J, Klopp N, Illig T, Guzmán C, Kasymov O, Akmatov M, Pessler F

2024Respiratory research25 (1) : 369

Differential transcriptomic host responses in the early phase of viral and bacterial infections in human lung tissue explants ex vivo

Sohail A, Waqas F, Braubach P, Czichon L, Samir M, Iqbal A, de Araujo L, Pleschka S, Steinert M, Geffers R, Pessler F

2024Science advances10 (39) : eadq7006

Systemic dysregulation and molecular insights into poor influenza vaccine response in the aging population

Kumar S, Zoodsma M, Nguyen N, Pedroso R, Trittel S, Riese P, Botey-Bataller J, Zhou L, Alaswad A, Arshad H, Netea M, Xu C, Pessler F, Guzmán C, Graca L, Li Y

2024Research square : rs.3.rs-4498597

Sex-specific epigenetic signatures of circulating urate and its increase after BCG vaccination

Liu Z, Crișan T, Qi C, Gupta M, Liu X, Moorlag S, Koeken V, de Bree L, Mourits V, Gao X, Baccarelli A, Schwartz J, Pessler F, Guzmán C, Li Y, Netea M, Joosten L, Xu C

2024Journal of translational medicine22 (1) : 620

Targeted metabolomics identifies accurate CSF metabolite biomarkers for the differentiation between COVID-19 with neurological involvement and CNS infections with neurotropic viral pathogens

Neu F, Nay S, Schuchardt S, Klawonn F, Skripuletz T, Suehs K, Pessler F

2024Trends in endocrinology and metabolism: TEM35 (7) : 561-562

Aconitate decarboxylase (ACOD1) has found a disease

Waqas F, Chen C, Pessler F

2023Journal of translational medicine21 (1) : 776

Elevated phospholipids and acylcarnitines C4 and C5 in cerebrospinal fluid distinguish viral CNS infections from autoimmune neuroinflammation

Al-Mekhlafi A, Waqas F, Krueger M, Klawonn F, Akmatov M, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Sühs K, Pessler F

2023Pathogens (Basel, Switzerland)12 (8) : 989

The Changing Epidemiology of Viral Hepatitis in a Post-Soviet Country-The Case of Kyrgyzstan

Akmatov M, Beisheeva N, Nurmatov A, Gulsunai S, Saikal K, Derkenbaeva A, Abdrahmanova Z, Prokein J, Klopp N, Illig T, Kasymov O, Nurmatov Z, Pessler F

2023PLoS pathogens19 (7) : e1011506

NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner

Waqas F, Shehata M, Elgaher W, Lacour A, Kurmasheva N, Begnini F, Kiib A, Dahlmann J, Chen C, Pavlou A, Poulsen T, Merkert S, Martin U, Olmer R, Olagnier D, Hirsch A, Pleschka S, Pessler F

2023Scientific reports13 (1) : 10360

Amino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1

Chen F, Yalcin I, Zhao M, Chen C, Blankenfeldt W, Pessler F, Büssow K

Posts

The scientist Dr. Fangfang Chen characterised the molecule itaconic acid © TWINCORE / Grabowski

07/07/2022

Cell protection, immunomodulation and virus inhibition by an endogenous substance

Previously unknown effects of citraconic acid described

The two scientists Fakhar Waqas (l.) and Frank Peßler in the laboratory

08/31/2023

Cancer drug works against viruses

TWINCORE researchers describe a mechanism that inhibits virus replication and protects cells from damage. Interestingly, a drug that has already been approved could prove useful in combating various viruses.

02/15/2022