Virology

Lauber Lab

Chris Lauber
Head

Prof. Chris Lauber

Publications

2024PLoS pathogens20 (9) : e1012509

The triglyceride-synthesizing enzyme diacylglycerol acyltransferase 2 modulates the formation of the hepatitis C virus replication organelle

Reichert I, Lee J, Weber L, Fuh M, Schlaeger L, Rößler S, Kinast V, Schlienkamp S, Conradi J, Vondran F, Pfaender S, Scaturro P, Steinmann E, Bartenschlager R, Pietschmann T, Heeren J, Lauber C, Vieyres G

2024Environment international190 : 108875

Pathogen dynamics and discovery of novel viruses and enzymes by deep nucleic acid sequencing of wastewater

Wyler E, Lauber C, Manukyan A, Deter A, Quedenau C, Teixeira Alves L, Wylezich C, Borodina T, Seitz S, Altmüller J, Landthaler M

2024Viruses16 (6) : 859

Analysis of Replication, Cell Division-Mediated Spread, and HBV Envelope Protein-Dependent Pseudotyping of Three Mammalian Delta-like Agents

Gnouamozi G, Zhang Z, Prasad V, Lauber C, Seitz S, Urban S

2024PLoS pathogens20 (4) : e1012163

Deep mining of the Sequence Read Archive reveals major genetic innovations in coronaviruses and other nidoviruses of aquatic vertebrates

Lauber C, Zhang X, Vaas J, Klingler F, Mutz P, Dubin A, Pietschmann T, Roth O, Neuman B, Gorbalenya A, Bartenschlager R, Seitz S

2024Nature communications15 (1) : 1173

Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor

Sake S, Zhang X, Rajak M, Urbanek-Quaing M, Carpentier A, Gunesch A, Grethe C, Matthaei A, Rückert J, Galloux M, Larcher T, Le Goffic R, Hontonnou F, Chatterjee A, Johnson K, Morwood K, Rox K, Elgaher W, Huang J, Wetzke M, Hansen G, Fischer N, Eléouët J, Rameix-Welti M, Hirsch A, Herold E, Empting M, Lauber C, Schulz T, Krey T, Haid S, Pietschmann T

2023Viruses15 (11) : 2248

Evolutionary Insight into the Association between New Jersey Polyomavirus and Humans

Aghebatrafat A, Lauber C, Merkel K, Fruth B, Langergraber K, Robbins M, Wittig R, Leendertz F, Calvignac-Spencer S

2023Frontiers in microbiology14 : 1144003

Viroid-like RNA-dependent RNA polymerase-encoding ambiviruses are abundant in complex fungi

Chong L, Lauber C

2022Biomolecules12 (8) : 1073

Opportunities and Challenges of Data-Driven Virus Discovery

Lauber C, Seitz S

2022PLoS biology20 (3) : e3001561

Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort

Lauber C, Gerl M, Klose C, Ottosson F, Melander O, Simons K

2022Current opinion in virology52 : 48-56

Bioinformatics of virus taxonomy: foundations and tools for developing sequence-based hierarchical classification

Gorbalenya A, Lauber C

Posts

New research group “Computational Virology” at TWINCORE

Group leader Chris Lauber funded by RESIST 

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Microscopic image of cells transfected with RSV. Green: RSV-F protein labelled with GFP in the cytoplasm of the cells, magenta: RSV-F protein, blue: cell nuclei. ©TWINCORE/Carpentier

New hope in the fight against RSV

TWINCORE researchers discover promising drug candidate 

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Two murine restriction factors limiting hepatitis C infection described

Research team at TWINCORE, with international collaborators, clarifies why mice are not susceptible to infection with hepatitis C virus 

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