2026Science Advances12 (25) : eaed4499
Respiratory syncytial viral load drives ciliated cell dedifferentiation and suppresses antiviral immunity
Berg K, Haid S, Vafadarnejad E, Carpentier A, Geffers R, Wiegmann B, Saliba A, Erhard F, Pietschmann T
Dr. Arnaud Carpentier
Postdoctoral Researcher
About
Arnaud Carpentier is a postdoctoral researcher at the Institute for Experimental Virology at TWINCORE. He studied biology in Lille and Paris (France) and graduated in 2009. He obtained his PhD at the Pierre and Marie Curie University (Paris) and worked on hepatitis C infection of primary human hepatocytes.
In 2010, he joined the Liver Disease Group of Dr T. Jake Liang at the National Institute of Health (NIH, Bethesda, USA) as a postdoctoral fellow. There, he focused on the development of new relevant in vitro and in vivo models for hepatitis B virus (HBV) and hepatitis C virus (HCV) infections using hepatocytes derived from human pluripotent stem cells (also known as HLCs).
In 2015, he joined the Institute for Experimental Virology at TWINCORE, where he investigated the innate immune response to HCV infection in HLCs. He now focuses his work on studying the interactions between hepatitis D virus and its host pathogens mainly using HLCs and single-cell RNA sequencing.
Research Lab
Publications
2026Gut : gutjnl-2025-337640
CD16+ γδ T cells mediate antibody-dependent cellular cytotoxicity and associate with viral control in chronic hepatitis B virus infection
Schröter P, Steppich K, Fernández Carrera L, Song Z, Klein S, Souleiman R, Urbanek-Quaing M, Lietzau A, Schnieders A, Freyer E, Bremer B, León-Lara X, Almeida V, Gutierrez Jauregui R, Von Kaisenberg C, Bruhn M, Meineke C, Kalinke U, Wedemeyer H, Prinz I, Ravens S, Carpentier A, Bartsch Y, Kraft A, Cornberg M
2025Jhep Reports : Innovation in Hepatology7 (8) : 101429
Single-cell analysis of mature hepatocytes reveals an IRF1-driven restriction of HDV infection
Lange F, Garn J, Bruhn M, Pietschmann T, Carpentier A
2024Antiviral Research234 : 106062
Host-targeting antivirals for chronic viral infections of the liver
Frericks N, Klöhn M, Lange F, Pottkämper L, Carpentier A, Steinmann E
2024Nature Communications15 (1) : 1173
Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor
Sake S, Zhang X, Rajak M, Urbanek-Quaing M, Carpentier A, Gunesch A, Grethe C, Matthaei A, Rückert J, Galloux M, Larcher T, Le Goffic R, Hontonnou F, Chatterjee A, Johnson K, Morwood K, Rox K, Elgaher W, Huang J, Wetzke M, Hansen G, Fischer N, Eléouët J, Rameix-Welti M, Hirsch A, Herold E, Empting M, Lauber C, Schulz T, Krey T, Haid S, Pietschmann T
Posts
How RSV manipulates the immune response in respiratory cells
TWINCORE researchers investigate gene activity in host cells
Towards the functional cure of hepatitis B
Research in Hannover is making important contributions to the field of infection medicine
Better insights into the hepatitis D virus
Hannover researchers develop stem cell-based infection model