Better fight against hepatitis E
Neutralising antibodies can prevent severe courses
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Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
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Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Immunology
Virology
Bacteriology
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2025mAbs17 (1) : 2465391
Combinatorial Fc modifications for complementary antibody functionality
Bartsch Y, Webb N, Burgess E, Kang J, Lauffenburger D, Julg B
2025Cell reports44 (3) : 115413
Distinctive CD8+ T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells
van der Sluis R, García-Rodríguez J, Nielsen I, Gris-Oliver A, Becker J, Costa B, Chaudhry M, Werner M, Laustsen A, Pedersen J, Gammelgaard K, Mogensen T, Kalinke U, Cicin-Sain L, Bak R, Kristensen L, Jakobsen M
2025Journal of natural products : 10.1021/acs.jnatprod.4c00394
Efficient and Selective Biosynthesis of a Precursor-Directed FK506 Analogue: Paving the Way for Click Chemistry
Goranovič D, Jenko B, Ramšak B, Podgoršek Berke A, Bedrač L, Horvat J, Šala M, Makuc D, Carriche G, Silva L, Lopez Krol A, Pšeničnik A, Durán Alonso M, Avbelj M, Stavber S, Plavec J, Sparwasser T, Müller R, Kosec G, Fujs Š, Petković H
Graalmann Lab
Immunology
Indirect effects of immunomodulatory drugs
Immunomodulatory drugs for rheumatic diseases specifically influence immune cells and messenger substances. This project investigates their effect on immune responses in order to find individually suitable therapies.
Kalinke Lab
Immunology
Virus control within the CNS
The project investigates the immune response of the central nervous system in viral infections, in particular the role of type I IFN, microglia and monocytes in the development of encephalitis and their influence on seizures and hippocampal damage.
Pessler Lab
Immunology
Cerebrospinal fluid biomarkers for early diagnosis and risk stratification of CNS infections
In collaboration with the Department of Neurology and the Metabolomics Department, the project is investigating metabolic products in cerebrospinal fluid in order to identify biomarkers for CNS infections and cell damage and to distinguish long COVID and viral from autoimmune diseases.
Pietschmann Lab
Virology
Host and viral factors that govern susceptibility to HCV and RSV
We are investigating why HCV infections sometimes heal spontaneously, but often become chronic, and why RSV infections are severe in some children. We use modern sequencing technologies to analyze the genetic characteristics of hosts and pathogens in order to understand susceptibility.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
