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Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2025The Journal of Infectious Diseases : jiaf654
Transient interferon-driven NK cell activation in acute hepatitis C
Strunz B, Zhan Q, Khera T, Hengst J, Jankovic M, Deterding K, Niehrs A, Cornberg M, Xu C, Wedemeyer H, Björkström N
2025Plos One20 (12) : e0337890
Dynamic growth risk of incidentally detected gallbladder polyps-A retrospective, single-center analysis
Heinrich S, Ten Thoren P, Behrendt P, Hagenah J, Wedemeyer H, Potthoff A, Maasoumy B
2025Journal of Autoimmunity158 : 103517
Humoral correlates of clinical response to thymectomy in myasthenia gravis
Sousa C, Terroba-Navajas P, Tzartos J, Orešković I, Pučić-Baković M, Lauc G, Bartsch Y, Kaminski H, Lünemann J
Kalinke Lab
Immunology
Virus control within the CNS
The project investigates the immune response of the central nervous system in viral infections, in particular the role of type I IFN, microglia and monocytes in the development of encephalitis and their influence on seizures and hippocampal damage.
Bartsch Lab
Immunology
Harnessing antibody Fc effector functions as therapeutic target
The project is researching how the effect of monoclonal antibodies can be improved. These antibodies are already being used successfully against viruses. The aim is to optimize the so-called Fc effector functions in order to fight infections even more effectively.
Pietschmann Lab
Virology
Principles of HCV assembly and entry and their role in virus persistence
We are investigating how the association of HCV with lipoproteins contributes to the persistence of the virus by influencing entry into liver cells and protecting against antibodies. The aim is to gain new insights for the development of an HCV vaccine.
Pietschmann Lab
Virology
Antiviral agents against HCV, RSV and coronavirus
We develop high-throughput screening assays to identify antiviral molecules against RSV and SARS-CoV-2. We use compound libraries, investigate new mechanisms of action and strive for innovative therapies.
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Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
