Infection research at the interface between clinical practice and basic research
At TWINCORE, we combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Apply for LISA 2025
Registration for the Lower Saxony International Summer Academy 2025 is open until 2025.
Find more information here!
A major step for HCV research
Research team from Hannover adapts hepatitis C virus to infect mouse liver cells
Read more
Better results through less stress
Researchers in Hannover have developed a new method for studying neuroinfections. This reduces errors in analysis and delivers more accurate results.
Read moreResearch
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Immunology
Virology
Bacteriology
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2025Archives of microbiology207 (2) : 47
Characterization of the host specificity of the SH3 cell wall binding domain of the staphylococcal phage 88 endolysin
Tham H, Chong L, Krishnan M, Khan A, Choi S, Tamura T, Yusoff K, Tan G, Song A
2025International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases : 107802
Acute respiratory tract infections during the first six years of life - results from the German birth cohort study LoewenKIDS
Klee B, Diexer S, Langer S, Gottschick C, Hartmann C, Glaser N, Horn J, Dorendorf E, Raupach-Rosin H, Hassan L, Rübsamen N, Meyer-Schlinkmann K, Guzman C, Heselich V, Battin E, Pietschmann T, Pieper D, Pletz M, Riese P, Trittel S, Thies S, von Kaisenberg C, Dressler F, Guthmann F, Oberhoff C, Schild R, Karch A, Mikolajczyk R
2025Chemistry (Weinheim an der Bergstrasse, Germany)31 (4) : e202403390
Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potential Against SARS-CoV-2
Jumde R, Jézéquel G, Saramago M, Frank N, Adam S, Cunha M, Bader C, Gunesch A, Köhler N, Johannsen S, Bousis S, Pietschmann T, Matos R, Müller R, Arraiano C, Hirsch A
Graalmann Lab
Immunology
Cell-selective targeting of immune cells
Immunomodulatory drugs can have systemic side effects. This project is testing nanocarriers that deliver drugs specifically into myeloid immune cells in order to reduce side effects and increase the local effect.
Pessler Lab
Immunology
Predictive biomarkers for a poor immune response to influenza vaccination in elderly individuals
Older people are at high risk of a poor immune response to the flu vaccine. Together with partners, we are looking for biomarkers and risk factors for this inadequate response and are investigating ways to improve the vaccination response.
Pietschmann Lab
Virology
Antiviral agents against HCV, RSV and coronavirus
We develop high-throughput screening assays to identify antiviral molecules against RSV and SARS-CoV-2. We use compound libraries, investigate new mechanisms of action and strive for innovative therapies.
Pietschmann Lab
Virology
Host and viral factors that govern susceptibility to HCV and RSV
We are investigating why HCV infections sometimes heal spontaneously, but often become chronic, and why RSV infections are severe in some children. We use modern sequencing technologies to analyze the genetic characteristics of hosts and pathogens in order to understand susceptibility.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
