Season's Greetings
TWINCORE wishes you happy holidays and a successful new year
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2026Nature Immunology : 10.1038/s41590-025-02387-1
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID
Kumar S, Li C, Zhou L, Zhan Q, Alaswad A, Volland S, Costa B, Krooss S, Klefenz I, Schmaus H, Zeuzem A, von Witzendorff D, Lickei H, Pueschel L, Kraft A, Cornberg M, Koczulla A, Pink I, Hoeper M, Xu C, Häussler S, Wiestler M, Netea M, Illig T, Sun J, Li Y
2026Infection and Immunity : e0045325
Pseudopaline-mediated zinc uptake by Pseudomonas aeruginosa drives clinically relevant phenotypes and infection outcomes
Bosc L, Sécher T, Ball G, Le Pennec D, Tribout M, Ba M, Bai Y, Ouerdane L, Arnoux P, Denis Y, Lei X, Bordi C, Heuzé-Vourc'h N, Häussler S, Gomez N, Voulhoux R
2026Clinical & Translational Immunology15 (1) : e70071
Immune activation and response dynamics of human iPSC-derived macrophages in tuberculosis infection models
Paasch D, Schevel H, Riehle A, Costa B, Toufaili H, Gehnen T, Dahlmann J, Pavlou A, Neehus A, Nguyen A, Schiering E, Buchegger T, Bustamante J, Hansen G, Kalinke U, Gulbins E, Grassmé H, Lachmann N
Kalinke Lab
Immunology
Immunological sensing of cytomegalovirus (CMV)
The project investigates how HCMV is recognized by the immune system and which mechanisms the virus uses to camouflage itself. The aim is to understand the immune reactions and develop therapies for severely affected patients.
Pietschmann Lab
Virology
Determinants of protective immunity in HCV: A gold standard for vaccine development
We are investigating how antibodies protect against HCV infection, in particular what properties they have during a healing infection. The aim is to identify antibodies that are important for an effective vaccine against HCV.
Pietschmann Lab
Virology
Host and viral factors that govern susceptibility to HCV and RSV
We are investigating why HCV infections sometimes heal spontaneously, but often become chronic, and why RSV infections are severe in some children. We use modern sequencing technologies to analyze the genetic characteristics of hosts and pathogens in order to understand susceptibility.
Behrendt Lab
Virology
Determinants of the Clinical Course of Infection
Human, potentially neutralizing antibodies against HEV have advanced the development of new detection methods for the virus in patient samples. Serological and functional analyses are used to determine markers for the course and treatment of chronic infections.
There are currently no events.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
