Better fight against hepatitis E
Neutralising antibodies can prevent severe courses
Infection research at the interface between clinical practice and basic research
TWINCORE was founded in 2008 by the Helmholtz Centre for Infection Research and the Hannover Medical School. We combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
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Research
We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2025Mabs17 (1) : 2465391
Combinatorial Fc modifications for complementary antibody functionality
Bartsch Y, Webb N, Burgess E, Kang J, Lauffenburger D, Julg B
2025Hepatology (baltimore, Md.) : 10.1097/HEP.0000000000001340
Reply: Refining epigenetic insights in HBV-Specific T Cell restoration
Chou Y, Cornberg M
2025Scientific Reports15 (1) : 10795
Therapeutic treatment of hepatitis E virus infection in pigs with a neutralizing monoclonal antibody
Hrabal I, Aliabadi E, Reiche S, Weber S, Holicki C, Schmid L, Fast C, Schröder C, Gutjahr B, Behrendt P, Groschup M, Eiden M
Graalmann Lab
Immunology
Indirect effects of immunomodulatory drugs
Immunomodulatory drugs for rheumatic diseases specifically influence immune cells and messenger substances. This project investigates their effect on immune responses in order to find individually suitable therapies.
Kalinke Lab
Immunology
Immunological sensing of cytomegalovirus (CMV)
The project investigates how HCMV is recognized by the immune system and which mechanisms the virus uses to camouflage itself. The aim is to understand the immune reactions and develop therapies for severely affected patients.
Pessler Lab
Immunology
Predictive biomarkers for a poor immune response to influenza vaccination in elderly individuals
Older people are at high risk of a poor immune response to the flu vaccine. Together with partners, we are looking for biomarkers and risk factors for this inadequate response and are investigating ways to improve the vaccination response.
Lauber Lab
Virology
Genetic determinants of severe RSV infection in infants
We are investigating how genetic variants influence the risk of severe RSV infections in infants. Exome sequencing and bioinformatic analyses are used to identify causal variants in immunity genes.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
