2024Genome biology25 (1) : 228
Real-time identification of epistatic interactions in SARS-CoV-2 from large genome collections
Innocenti G, Obara M, Costa B, Jacobsen H, Katzmarzyk M, Cicin-Sain L, Kalinke U, Galardini M
Prof. Dr. Marco Galardini
Research Group Leader
Projects
Galardini Lab
Bacteriology
Genotype to phenotype studies in bacteria
By applying statistical genetics methods to pathogen genome sequences, we aim to identify and validate genetic determinants of phenotypes such as pathogenicity, virulence and antibiotic resistance, e.g. in E. coli and P. aeruginosa.
Galardini Lab
Bacteriology
Testing the impact of genetic backgrounds on antimicrobial resistance
Population genetic studies show that genetic variability between bacterial strains can influence the evolution of antimicrobial resistance. Using automated laboratory evolution (ALE), we are investigating how genetic backgrounds control AMR evolution.
Galardini Lab
Bacteriology
Pangenome wide prediction of gene function
Thanks to high-throughput sequencing, genome sequences of hundreds of bacterial strains can be analyzed efficiently, revealing differences of up to 60 % in gene content, as in E. coli. With the help of machine learning, we want to better predict the functions of accessory genes and decipher their contribution to survival in specialized niches.
Publications
2024Nature communications15 (1) : 952
Anti-CRISPR Anopheles mosquitoes inhibit gene drive spread under challenging behavioural conditions in large cages
D'Amato R, Taxiarchi C, Galardini M, Trusso A, Minuz R, Grilli S, Somerville A, Shittu D, Khalil A, Galizi R, Crisanti A, Simoni A, Müller R
2023Microbial genomics9 (11) : 001129
Reduced ambiguity and improved interpretability of bacterial genome-wide associations using gene-cluster-centric k-mers
Sommer H, Djamalova D, Galardini M
Posts
New research group "Systems Biology of Microbial Communities" launched at TWINCORE
RESIST professorship for Marco Galardini
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More than the sum of the parts
TWINCORE researchers show role of epistatic interaction in the omicron variant of SARS-CoV-2 virus .
Read moreHow does an intestinal germ become a pathogen?
Scientists are looking for a connection between bacterial genes and disease severity
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