2026Virology623 : 111011
Augmenting hepatitis C E1E2 glycoprotein antibody detection via an alternative lectin-assisted mannose-binding ELISA
Youssef M, Döpke M, Ginkel C, Ye K, Bankwitz D, Krey T, Pietschmann T, Sheldon J
Dr. Julie Sheldon
Teamleader Hepatitis Viruses
About
Julie Sheldon works as a postdoc at the Institute for Experimental Virology at TWINCORE. She studied microbiology at the University of Liverpool (1991-1994) and completed her master's degree in the group of Thomas Schulz at the Hannover Medical School (MHH) in 2002. After completing her doctorate in Madrid in 2008, she received several research grants and worked, among others, in the group of Prof. Charles Rice in New York and Prof. Esteban Domingo in Madrid. In 2013, Julie moved to Hannover to work in the group of Professor Thomas Pietschmann, where she is investigating the tropism of the hepatitis C virus.
Research Lab
Publications
2025Jhep Reports : Innovation in Hepatology7 (5) : 101328
Adapted hepatitis C virus clone infects innate immunity-deficient mouse hepatocytes with minimal human HCV entry factors
Sheldon J, Winkler M, Yuan Q, Frericks N, Phillip Brown R, Miskey C, Gödecke N, Behme S, Rox K, Mysegades G, Vondran F, Wirth D, Pietschmann T
2024Journal of Virology98 (3) : e0192123
Unraveling the dynamics of hepatitis C virus adaptive mutations and their impact on antiviral responses in primary human hepatocytes
Frericks N, Brown R, Reinecke B, Herrmann M, Brüggemann Y, Todt D, Miskey C, Vondran F, Steinmann E, Pietschmann T, Sheldon J
2023Biorxiv : The Preprint Server for Biology : 2023.11.22.568224
Hepatitis C virus cell culture adaptive mutations enhance cell culture propagation by multiple mechanisms but boost antiviral responses in primary human hepatocytes
Frericks N, Brown R, Reinecke B, Herrmann M, Brüggemann Y, Todt D, Miskey C, Vondran F, Steinmann E, Pietschmann T, Sheldon J
2023Microbiology Spectrum11 (4) : e0128423
Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses
Zhang Y, Kinast V, Sheldon J, Frericks N, Todt D, Zimmer M, Caliskan N, Brown R, Steinmann E, Pietschmann T
Posts
TWINCORE team participates in Hannover Marathon
Relay team comes in at rank 536
A major step for HCV research
Research team from Hannover adapts hepatitis C virus to infect mouse liver cells
Two murine restriction factors limiting hepatitis C infection described
Research team at TWINCORE, with international collaborators, clarifies why mice are not susceptible to infection with hepatitis C virus