Publications

2024Respiratory research25 (1) : 369

Differential transcriptomic host responses in the early phase of viral and bacterial infections in human lung tissue explants ex vivo

Sohail A, Waqas F, Braubach P, Czichon L, Samir M, Iqbal A, de Araujo L, Pleschka S, Steinert M, Geffers R, Pessler F

2024Trends in endocrinology and metabolism: TEM35 (7) : 561-562

Aconitate decarboxylase (ACOD1) has found a disease

Waqas F, Chen C, Pessler F

2023Journal of translational medicine21 (1) : 776

Elevated phospholipids and acylcarnitines C4 and C5 in cerebrospinal fluid distinguish viral CNS infections from autoimmune neuroinflammation

Al-Mekhlafi A, Waqas F, Krueger M, Klawonn F, Akmatov M, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Sühs K, Pessler F

2023PLoS pathogens19 (7) : e1011506

NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner

Waqas F, Shehata M, Elgaher W, Lacour A, Kurmasheva N, Begnini F, Kiib A, Dahlmann J, Chen C, Pavlou A, Poulsen T, Merkert S, Martin U, Olmer R, Olagnier D, Hirsch A, Pleschka S, Pessler F

2023Stem cell research69 : 103090

Generation of two human NRF2 knockout iPSC clones using CRISPR/Cas9 editing

Merkert S, Haase A, Dahlmann J, Göhring G, Waqas F, Pessler F, Martin U, Olmer R

2022Clinical and translational medicine12 (7) : e931

ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives

Waqas S, Sohail A, Nguyen A, Usman A, Ludwig T, Wegner A, Malik M, Schuchardt S, Geffers R, Winterhoff M, Merkert S, Martin U, Olmer R, Lachmann N, Pessler F

2022Nature metabolism4 (5) : 534-546

Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism

Chen F, Elgaher W, Winterhoff M, Büssow K, Waqas F, Graner E, Pires-Afonso Y, Casares Perez L, de la Vega L, Sahini N, Czichon L, Zobl W, Zillinger T, Shehata M, Pleschka S, Bähre H, Falk C, Michelucci A, Schuchardt S, Blankenfeldt W, Hirsch A, Pessler F

2022The Journal of clinical investigation132 (3) : e141573

Congenital deficiency reveals critical role of ISG15 in skin homeostasis

Malik M, Waqas S, Zeitvogel J, Cheng J, Geffers R, Gouda Z, Elsaman A, Radwan A, Schefzyk M, Braubach P, Auber B, Olmer R, Müsken M, Roesner L, Gerold G, Schuchardt S, Merkert S, Martin U, Meissner F, Werfel T, Pessler F

2022PLoS pathogens18 (1) : e1010219

Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection

Sohail A, Iqbal A, Sahini N, Chen F, Tantawy M, Waqas S, Winterhoff M, Ebensen T, Schultz K, Geffers R, Schughart K, Preusse M, Shehata M, Bähre H, Pils M, Guzman C, Mostafa A, Pleschka S, Falk C, Michelucci A, Pessler F