Publicly-financed research in Germany is divided into three parts: the universities and colleges of further education research and work locally. Institutes such as the Helmholtz Association, Max Planck Society and Leibniz Association are active throughout Germany. Moreover, there are also ministerial research institutions which on the one hand undertake sovereign tasks, but also conduct research and supply political consultation. In the scope of the Federal Ministry of Health the Paul Ehrlich Institute (PEI) in Langen and the Federal Institute for Drugs and Medical Devices (BfArM) in Bonn are responsible for the approval of clinical trials in Germany. In addition, both establishments also play a key role in the granting of market approval for new pharmaceuticals in Europe. TWINCORE is already closely interlinked with local and national research establishments and also maintains intensive scientific interaction with the two ministerial research institutions PEI and BfArM.