PD Dr. Matthias Lochner

Group Leader

+49 (0)511-220027-202
+49 (0)511-220027-203

Dr. Matthias Lochner is a trained immunologist with a special focus on the intestinal immune response during infection and inflammation. Matthias Lochner studied biology at the Technical University in Munich (TUM), focusing on the role of the cytokine IL-18 in infection and intestinal inflammation. In 2005, he moved on for a postdoc position in the “Laboratory of Lymphoid Tissue Development" lead by Dr. Gérard Eberl at the Pasteur Institute in Paris, where he continued to work on the topic of intestinal immune regulation. This area of research has gained enormous attention during the recent years, when it was revealed that cells expressing the transcription factor retinoic acid-related orphan receptor gamma (ROR?)t, such as Th17 cells and innate lymphoid cells (ILC)3, contribute significantly to the regulation of intestinal immunity. With the research that Matthias Lochner conducted during his postdoc time at the Pasteur Institute, he was able to shed light into critical functional aspects of ROR?t-expressing cells and to contribute to the current knowledge on the regulatory mechanisms of the intestinal immune system. In 2010 Matthias Lochner joined the Institute of Infection Immunology at Twincore. Here, he continued his research as a junior group leader, with his work not only centering on the impact of Th17 immunity during intestinal bacterial infections and the special relationship between Th17 cells and Treg cells, but also on dissecting the role of specific intestinal innate immune cells such as dendritic cells and ILC during gut infection and inflammation.