Research foci Infection Immunology
Immunometabolism in mucosal infection and inflammation
Targeting the intracellular metabolism of immune cells is a promising novel strategy for immunomodulation. We are striving to understand the basis for the different metabolic requirements of specific intestinal cell populations and to use this knowledge in order to develop novel translational approaches to modulate the immune responses in mucosal organs.
Immune cell function in mucosal infection and inflammation
The immune system of the gut faces a great challenge to guarantee for the integrity of the host tissue, without compromising the ability to develop tolerance against harmless foodborne antigens and the beneficial intestinal microbiota. In addition, the intestinal immune system must be able to mount a rapid and effective response to pathogens, in order to protect the host from harmful gastro-intestinal infections. We study specific immune cell subsets in order to understand the mechanisms that are responsible for the induction and regulation of inflammatory immune responses during intestinal infections and inflammation.