• Joean O, Hueber A, Feller F, Jirmo AC, Lochner M, Dittrich AM, Albrecht Melanie (2017) Suppression of Th17-polarized airway inflammation by rapamycin. Sci Rep 7(1): 15336.

    • Zischke J, Mamareli P, Pokoyski C, Gabaev I, Buyny S, Jacobs R, Falk CS, Lochner M, Sparwasser T, Schulz TF, Kay-Fedorov PC (2017) The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion. PLoS Pathog 13(6): 1-26.

    • Alissafi T, Banos A, Boon L, Sparwasser T, Ghigo A, Wing K, Vassilopoulos D, Boumpas D, Chavakis T, Cadwell K, Verginis P (2017) Tregs restrain dendritic cell autophagy to ameliorate autoimmunity. J Clin Invest 127(7): 2789-2804.

    • Friedrich C, Mamareli P, Thiemann S, Kruse F, Wang Z, Holzmann B, Strowig T, Sparwasser T, Lochner M (2017) MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium. PLOS Pathogens 13(5): 1-26.

    • Popovic B, Golemac M, Podlech J, Zeleznjak J, Bilic-Zulle L, Lukic ML, Cicin-Sain L, Reddehase MJ, Sparwasser T, Krmpotic A, Jonjic S (2017) IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection. PLoS Pathog 13(4): 1-23.

    • van der Vlugt L, Obieglo K, Ozir-Fazalalikhan A, Sparwasser T, Haeberlein S, Smits HH (2017) Schistosome-induced pulmonary B cells inhibit allergic airway inflammation and display a reduced Th2-driving function. Int J Parasitol 47(9): 545-554.

    • Minarrieta L, Ghorbani P, Sparwasser T, Berod L (2017) Metabolites: deciphering the molecular language between DCs and their environment. Semin Immunopathol 39(2): 177-198.

    in press

    • Singpiel A, Kramer J, Maus R, Stolper J, Bittersohl LF, Gauldie J, Kolb M, Welte T, Sparwasser T, Maus UA (in press) Adenoviral vector-mediated GM-CSF gene transfer improves anti-mycobacterial immunity in mice - role of regulatory T cells. Immunobiology n/a(n/a): n/a.

    • Semitekolou M, Morianos I, Banos A, Konstantopoulos D, Adamou-Tzani M, Sparwasser T, Xanthou G (in press) Dendritic cells conditioned by activin-A-induced regulatory T cells exhibit enhanced tolerogenic properties and protect against experimental asthma. J Allergy Clin Immunol n/a(n/a): n/a.


    • Almeida L, Lochner M, Berod L, Sparwasser T (2016) Metabolic pathways in T cell activation and lineage differentiation. Semin Immunol 28(5): 514 - 524.

    • Berod L, Sparwasser T (2016) pDCs Take a Deep Breath to Fight Viruses. Immunity 44(6): 1246-1248.

    • Buettner M, Lochner M (2016) Development and Function of Secondary and Tertiary Lymphoid Organs in the Small Intestine and the Colon. Front Immunol 7 342.

    • Dudek M, Puttur F, Arnold-Schrauf C, Kuhl AA, Holzmann B, Henriques-Normark B, Berod L, Sparwasser T (2016) Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection. Mucosal Immunol 9(5): 1288-1302.

    • Freitag J, Berod L, Kamradt T, Sparwasser T (2016) Immunometabolism and autoimmunity. Immunol Cell Biol 94(10): 925-934.

    • Knuschke T, Rotan O, Bayer W, Sokolova V, Hansen W, Sparwasser T, Dittmer U, Epple M, Buer J, Westendorf AM (2016) Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection. Retrovirology 13(1).

    • Mykicki N, Herrmann AM, Schwab N, Deenen R, Sparwasser T, Limmer A, Wachsmuth L, Klotz L, Kohrer K, Faber C, Wiendl H, Luger TA, Meuth SG, Loser K (2016) Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci Transl Med 8(362): 362ra146.

    • Navarro S, Pickering DA, Ferreira IB, Jones L, Ryan S, Troy S, Leech A, Hotez PJ, Zhan B, Laha T, Prentice R, Sparwasser T, Croese J, Engwerda CR, Upham JW, Julia V, Giacomin PR, Loukas A (2016) Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Sci Transl Med 8(362): 362ra143.

    • Perdicchio M, Ilarregui JM, Verstege MI, Cornelissen LAM, Schetters STT, Engels S, Ambrosini M, Kalay H, Veninga H, den Haan JMM, van Berkel LA, Samsom JN, Crocker PR, Sparwasser T, Berod L, Garcia-Vallejo JJ, van Kooyk Y, Unger WWJ (2016) Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells. Proc Natl Acad Sci U S A 113(12): 3329-3334.

    • Puttur F, Francozo M, Solmaz G, Bueno C, Lindenberg M, Gohmert M, Swallow M, Tufa D, Jacobs R, Lienenklaus S, Kühl A A, Borkner L, Cicin-Sain L, Holzmann B, Wagner H, Berod L, Sparwasser T (2016) Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via \TLR9\ and MyD88 Signaling. Cell Reports 17(4): 1113 - 1127.

    • Raha S, Raud B, Oberdörfer L, Castro CN, Schreder A, Freitag J, Longerich T, Lochner M, Sparwasser T, Berod L, Koenecke C, Prinz I (2016) Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease. Eur J Immunol 46(9): 2233-2238.

    • Smith KA, Filbey KJ, Reynolds LA, Hewitson JP, Harcus Y, Boon L, Sparwasser T, Hammerling G, Maizels RM (2016) Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunol 9(2): 428-443.

    • Win SJ, Kühl AA, Sparwasser T, Hünig T, Kamradt T (2016) In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice. Eur J Immunol 46(5): 1193-1202.

    • Yang BH, Hagemann S, Mamareli P, Lauer U, Hoffmann U, Beckstette M, Föhse L, Prinz I, Pezoldt J, Suerbaum S, Sparwasser T, Hamann A, Floess S, Huehn J, Lochner M (2016) Foxp3 T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol 9(2): 444-457.


    • Akeus P, Langenes V, Kristensen J, von Mentzer A, Sparwasser T, Raghavan S, Quiding-Jarbrink M (2015) Treg-cell depletion promotes chemokine production and accumulation of CXCR3 conventional T cells in intestinal tumors. Eur J Immunol 45(6): 1654-1666.

    • Alissafi T, Hatzioannou A, Ioannou M, Sparwasser T, Grun JR, Grutzkau A, Verginis P (2015) De Novo-Induced Self-Antigen-Specific Foxp3+ Regulatory T Cells Impair the Accumulation of Inflammatory Dendritic Cells in Draining Lymph Nodes. J Immunol 194(12): 5812-5824.

    • Annemann M, Wang Z, Plaza-Sirvent C, Glauben R, Schuster M, Ewald Sander F, Mamareli P, Kuhl AA, Siegmund B, Lochner M, Schmitz I (2015) IkappaBNS Regulates Murine Th17 Differentiation during Gut Inflammation and Infection. J Immunol 194(6): 2888-2898.

    • Arnold-Schrauf C, Berod L, Sparwasser T (2015) Dendritic cell-specific targeting of MyD88 signalling pathways in vivo. Eur J Immunol 45(1): 32-39.

    • Bolton HA, Zhu E, Terry AM, Guy TV, Koh WP, Tan SY, Power CA, Bertolino P, Lahl K, Sparwasser T, Shklovskaya E, de St. Groth BF (2015) Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease. J Clin Invest 125(9): 3627-3641.

    • Buettner M, Dittrich-Breiholz O, Falk CS, Lochner M, Smoczek A, Menzel F, Bornemann M, Bode U (2015) Stromal cells as trend-setters for cells migrating into the lymph node. Mucosal Immunol 8(3): 640-649.

    • Castro CN, Freitag J, Berod L, Lochner M, Sparwasser T (2015) Microbe-associated immunomodulatory metabolites: Influence on T cell fate and function. Mol Immunol 68(2 Pt C): 575-584.

    • Dhainaut M, Coquerelle C, Uzureau S, Denoeud J, Acolty V, Oldenhove G, Galuppo A, Sparwasser T, Thielemans K, Pays E, Yagita H, Borst J, Moser M (2015) Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells. EMBO J 34(10): 1336-1348.

    • Khan AR, Amu S, Saunders SP, Hams E, Blackshields G, Leonard MO, Weaver CT, Sparwasser T, Sheils O, Fallon PG (2015) Ligation of TLR7 on CD19 CD1d B cells suppresses allergic lung inflammation via regulatory T cells. Eur J Immunol 45(6): 1842-1854.

    • Khan AR, Hams E, Floudas A, Sparwasser T, Weaver CT, Fallon PG (2015) PD-L1(hi) B cells are critical regulators of humoral immunity. Nat Commun 6 5997.

    • Legoux FP, Lim JB, Cauley A W, Dikiy S, Ertelt J, Mariani TJ, Sparwasser T, Way S S, Moon JJ (2015) CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion. Immunity 43(5): 896 - 908.

    • Lochner M, Berod L, Sparwasser T (2015) Fatty acid metabolism in the regulation of T cell function. Trends Immunol 36(2): 81-91.

    • Lochner M, Wang Z, Sparwasser T (2015) Chapter Five - The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells. 136 99 - 129.

    • Mahapatra S, Albrecht M, Baru AM, Sparwasser T, Herrick C, Dittrich AM (2015) Superior Suppressive Capacity of Skin Tregs Compared to Lung Tregs in a Model of Epicutaneous Priming. J Invest Dermatol 135(10): 2418-2426.

    • Molina MA, Diaz AM, Hesse C, Ginter W, Gentilini MV, Nunez GG, Canellada AM, Sparwasser T, Berod L, Castro MS, Manghi MA (2015) Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production. PLoS One 10(5): e0127262.

    • Niedzielska M, Raffi FA, Tel J, Muench S, Jozefowski K, Alati N, Lahl K, Mages J, Billmeier U, Schiemann M, Appelt UK, Wirtz S, Sparwasser T, Hochrein H, Figdor CG, Keyse SM, Lang R (2015) Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-beta Production. J Immunol 195(4): 1753-1762.

    • Schuhmann MK, Kraft P, Stoll G, Lorenz K, Meuth SG, Wiendl H, Nieswandt B, Sparwasser T, Beyersdorf N, Kerkau T, Kleinschnitz C (2015) CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke. J Cereb Blood Flow Metab 35(1): 6-10.

    • Tebartz C, Horst SA, Sparwasser T, Huehn J, Beineke A, Peters G, Medina E (2015) A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression during Staphylococcus aureus Infection. J Immunol 194(3): 1100-1111.

    • Torow N, Yu K, Hassani K, Freitag J, Schulz O, Basic M, Brennecke A, Sparwasser T, Wagner N, Bleich A, Lochner M, Weiss S, Forster R, Pabst O, Hornef MW (2015) Active suppression of intestinal CD4TCRalphabeta T-lymphocyte maturation during the postnatal period. Nat Commun 6 7725.

    • Unger WW, Mayer CT, Engels S, Hesse C, Perdicchio M, Puttur F, Streng-Ouwehand I, Litjens M, Kalay H, Berod L, Sparwasser T, van Kooyk Y (2015) Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression. Oncoimmunology 4(8): e970462.

    • Yang BH, Floess S, Hagemann S, Deyneko IV, Groebe L, Pezoldt J, Sparwasser T, Lochner M, Huehn J (2015) Development of a unique epigenetic signature during in vivo Th17 differentiation. Nucleic Acids Res 43(3): 1537-1548.

    • Yodoi K, Yamashita T, Sasaki N, Kasahara K, Emoto T, Matsumoto T, Kita T, Sasaki Y, Mizoguchi T, Sparwasser T, Hirata KI (2015) Foxp3+ Regulatory T Cells Play a Protective Role in Angiotensin II-Induced Aortic Aneurysm Formation in Mice. Hypertension 65(4): 889-895.


    • Arnold-Schrauf C, Dudek M, Dielmann A, Pace L, Swallow M, Kruse F, Kuhl AA, Holzmann B, Berod L, Sparwasser T (2014) Dendritic Cells Coordinate Innate Immunity via MyD88 Signaling to Control Listeria monocytogenes Infection. Cell Rep 6(4): 698-708.

    • Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bahre H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Muller R, Lochner M, Sparwasser T (2014) De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 20(11): 1327-1333.

    • Berod L, Stuve P, Swallow M, Arnold-Schrauf C, Kruse F, Gentilini MV, Freitag J, Holzmann B, Sparwasser T (2014) MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection. Eur J Immunol 44(5): 1399-1409.

    • Berod L, Stuve P, Varela F, Behrends J, Swallow M, Kruse F, Krull F, Ghorbani P, Mayer CT, Holscher C, Sparwasser T (2014) Rapid Rebound of the Treg Compartment in DEREG Mice Limits the Impact of Treg Depletion on Mycobacterial Burden, but Prevents Autoimmunity. PLoS One 9(7): e102804.

    • Blankenhaus B, Reitz M, Brenz Y, Eschbach ML, Hartmann W, Haben I, Sparwasser T, Huehn J, Kuhl A, Feyerabend TB, Rodewald HR, Breloer M (2014) Foxp3(+) Regulatory T Cells Delay Expulsion of Intestinal Nematodes by Suppression of IL-9-Driven Mast Cell Activation in BALB/c but Not in C57BL/6 Mice. PLoS Pathog 10(2): e1003913.

    • Chrobak P, Afkhami S, Priceputu E, Poudrier J, Meunier C, Hanna Z, Sparwasser T, Jolicoeur P (2014) HIV Nef Expression Favors the Relative Preservation of CD4+ T Regulatory Cells That Retain Some Important Suppressive Functions. J Immunol 192(4): 1681-1692.

    • Ehrlich A, Moreno Castilho T, Goldsmith-Pestana K, Chae WJ, Bothwell AL, Sparwasser T, McMahon-Pratt D (2014) The Immunotherapeutic Role of Regulatory T Cells in Leishmania (Viannia) panamensis Infection. J Immunol 193(6): 2961-2970.

    • Espinoza Mora Mdel R, Steeg C, Tartz S, Heussler V, Sparwasser T, Link A, Fleischer B, Jacobs T (2014) Depletion of Regulatory T Cells Augments a Vaccine-Induced T Effector Cell Response against the Liver-Stage of Malaria but Fails to Increase Memory. PLoS One 9(8): e104627.

    • Ganesh V, Baru AM, Hesse C, Friedrich C, Glage S, Gohmert M, Janke C, Sparwasser T (2014) Salmonella Typhimurium Infection Induced CD11b+Gr1+ Cells Ameliorate Allergic Airway Inflammation. Infect Immun 82(3): 1052-1063.

    • Jost NH, Abel S, Hutzler M, Sparwasser T, Zimmermann A, Roers A, Muller W, Klopfleisch R, Hengel H, Westendorf AM, Buer J, Hansen W (2014) Regulatory T cells and T-cell-derived IL-10 interfere with effective anti-cytomegalovirus immune response. Immunol Cell Biol 92(10): 860-871.

    • Lindenberg M, Solmaz G, Puttur F, Sparwasser T (2014) Mouse cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells. J Virol 11 145.

    • Mayer CT, Ghorbani P, Kuhl AA, Stuve P, Hegemann M, Berod L, Gershwin ME, Sparwasser T (2014) Few Foxp3 regulatory T cells are sufficient to protect adult mice from lethal autoimmunity. Euro J Immunol 44(10): 2990-3002.

    • Mayer CT, Ghorbani P, Nandan A, Dudek M, Arnold-Schrauf C, Hesse C, Berod L, Stuve P, Puttur F, Merad M, Sparwasser T (2014) Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow. Blood 124(20): 3081-3091.

    • Mayer CT, Lahl K, Milanez-Almeida P, Watts D, Dittmer U, Fyhrquist N, Huehn J, Kopf M, Kretschmer K, Rouse B, Sparwasser T (2014) Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice. Immun Inflamm Dis 2(3): 162-165.

    • Mayer CT, Sparwasser T (2014) Assessing the suppressive activity of foxp3(+) regulatory T cells. Methods Mol Biol 1193 85-96.

    • Mayer CT, Tian L, Hesse C, Kuhl AA, Swallow M, Kruse F, Thiele M, Gershwin ME, Liston A, Sparwasser T (2014) Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals. J Autoimmun 50 23-32.

    • Meyer Zu Horste G, Cordes S, Mausberg AK, Zozulya AL, Wessig C, Sparwasser T, Mathys C, Wiendl H, Hartung HP, Kieseier BC (2014) FoxP3+ Regulatory T Cells Determine Disease Severity in Rodent Models of Inflammatory Neuropathies. PLoS One 9(10): e108756.

    • Pastille E, Bardini K, Fleissner D, Adamczyk A, Frede A, Wadwa M, von Smolinski D, Kasper S, Sparwasser T, Gruber AD, Schuler M, Sackaguchi S, Roers A, Muller W, Hansen W, Buer J, Westendorf AM (2014) Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer. Cancer Res 74(16): 4258-4269.

    • Pessler F, Ogdie AR, Mayer CT, Kretzschmar WW, Dai L, Elsaman AM, Einhorn E, Krenn V, Schumacher HR (2014) Amyloid arthropathy associated with multiple myeloma: polyarthritis without synovial infiltration of CD20+ or CD38+ cells. Amyloid 21(1): 28-34.

    • Petzold C, Steinbronn N, Gereke M, Strasser RH, Sparwasser T, Bruder D, Geffers R, Schallenberg S, Kretschmer K (2014) Fluorochrome-based definition of naturally occurring Foxp3 regulatory T cells of intra- and extrathymic origin. Euro J Immunol 44(12): 3632-3645.

    • Schulze B, Piehler D, Eschke M, von Buttlar H, Kohler G, Sparwasser T, Alber G (2014) CD4 FoxP3 regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection. European Journal of Immnuology 44(12): 3596-3604.

    • Villalta SA, Rosenthal W, Martinez L, Kaur A, Sparwasser T, Tidball JG, Margeta M, Spencer MJ, Bluestone JA (2014) Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy. Sci Transl Med 6(258): 258ra142.

    • Wang Y, Sparwasser T, Figlin R, Kim HL (2014) Foxp3+ T cells inhibit antitumor immune memory modulated by mTOR inhibition. Cancer Res 74(8): 2217-2228.

    • Wang Z, Friedrich C, Hagemann SC, Korte WH, Goharani N, Cording S, Eberl G, Sparwasser T, Lochner M (2014) Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium. Mucosal Immunol 7(6): 1290-1301.


    • Akhmetzyanova I, Zelinskyy G, Schimmer S, Brandau S, Altenhoff P, Sparwasser T, Dittmer U (2013) Tumor-specific CD4(+) T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells. Cancer Immunol Immunother 62(2): 257-271.

    • Chai Q, Onder L, Scandella E, Gil-Cruz C, Perez-Shibayama C, Cupovic J, Danuser R, Sparwasser T, Luther SA, Thiel V, Rulicke T, Stein JV, Hehlgans T, Ludewig B (2013) Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity. Immunity 38(5): 1013-1024.

    • Elsaman AM, Radwan AR, Akmatov MK, Della Beffa C, Walker A, Mayer CT, Dai L, Nativ S, Rygg M, Atsali E, Saijo K, Ogdie AR, Srinivasulu N, Fathi N, Ralph Schumacher H, Pessler F (2013) Amyloid arthropathy associated with multiple myeloma: A systematic analysis of 101 reported cases. Semin Arthritis Rheum 43(3): 405-412.

    • Fernandez MA, Yu U, Zhang G, White R, Sparwasser T, Alexander SI, Jones CA (2013) Treg depletion attenuates the severity of skin disease from ganglionic spread after HSV-2 flank infection. Virology 447(1-2): 9-20.

    • Hesse C, Ginter W, Forg T, Mayer CT, Baru AM, Arnold-Schrauf C, Unger WW, Kalay H, van Kooyk Y, Berod L, Sparwasser T (2013) In vivo targeting of human DC-SIGN drastically enhances CD8 T-cell-mediated protective immunity. Eur J Immunol 43(10): 2543-2553.

    • Hu M, Wang C, Zhang G, Saito M, Wang Y, Fernandez M, Qian Y, Wang Y, Sawyer A, Hawthorne W, Jones C, Sparwasser T, Bishop A, Sharland A, O'Connell P, Alexander S (2013) Graft Infiltrating Foxp3 Tregs in Spontaneously Tolerant Renal A Allografts Express High Levels of CXCR3 and BLIMP-1. Am J Transplant 13(11): 2819-2830.

    • Kanjarawi R, Dy M, Bardel E, Sparwasser T, Dubois B, Mecheri S, Kaiserlian D (2013) Regulatory CD4(+)Foxp3(+) T Cells Control the Severity of Anaphylaxis. PLoS One 8(7): e69183.

    • Kleinschnitz C, Kraft P, Dreykluft A, Hagedorn I, Gobel K, Schuhmann MK, Langhauser F, Helluy X, Schwarz T, Bittner S, Mayer CT, Brede M, Varallyay C, Pham M, Bendszus M, Jakob P, Magnus T, Meuth SG, Iwakura Y, Zernecke A, Sparwasser T, Nieswandt B, Stoll G, Wiendl H (2013) Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 121(4): 679-691.

    • Klingenberg R, Gerdes N, Badeau RM, Gistera A, Strodthoff D, Ketelhuth DF, Lundberg AM, Rudling M, Nilsson SK, Olivecrona G, Zoller S, Lohmann C, Luscher TF, Jauhiainen M, Sparwasser T, Hansson GK (2013) Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest 123(3): 1323-1334.

    • Kuhlhorn F, Rath M, Schmoeckel K, Cziupka K, Nguyen HH, Hildebrandt P, Hunig T, Sparwasser T, Huehn J, Potschke C, Broker BM (2013) Foxp3(+) regulatory T cells are required for recovery from severe sepsis. PLoS One 8(5): e65109.

    • Layland LE, Straubinger K, Ritter M, Loffredo-Verde E, Garn H, Sparwasser T, Prazeres da Costa C (2013) Schistosoma mansoni-Mediated Suppression of Allergic Airway Inflammation Requires Patency and Foxp3(+) Treg Cells. PLoS Negl Trop Dis 7(8): e2379.

    • Martin B, Auffray C, Delpoux A, Pommier A, Durand A, Charvet C, Yakonowsky P, de Boysson H, Bonilla N, Audemard A, Sparwasser T, Salomon BL, Malissen B, Lucas B (2013) Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells. Nat Commun 4 2209.

    • Mayer CT, Huntenburg J, Nandan A, Schmitt E, Czeloth N, Sparwasser T (2013) CD4 blockade directly inhibits mouse and human CD4 T cell functions independent of Foxp3 Tregs. J Autoimmun 47 73-82.

    • Pasquet L, Douet JY, Sparwasser T, Romagnoli P, van Meerwijk JP (2013) Long term prevention of chronic allograft rejection by regulatory T cell immunotherapy involves host Foxp3-expressing T cells. Blood 121(21): 4303-4310.

    • Petzold C, Riewaldt J, Watts D, Sparwasser T, Schallenberg S, Kretschmer K (2013) Foxp3(+) regulatory T cells in mouse models of type 1 diabetes. J Diabetes Res 2013 940710.

    • Puttur F, Arnold-Schrauf C, Lahl K, Solmaz G, Lindenberg M, Mayer CT, Gohmert M, Swallow M, van Helt C, Schmitt H, Nitschke L, Lambrecht BN, Lang R, Messerle M, Sparwasser T (2013) Absence of Siglec-H in MCMV Infection Elevates Interferon Alpha Production but Does Not Enhance Viral Clearance. PLoS Pathog 9(9): e1003648.

    • Rosalia RA, Stepanek I, Pollakova V, Simova J, Bieblova J, Indrova M, Moravcova S, Pribylova H, Bontkes HJ, Bubenik J, Sparwasser T, Reinis M (2013) Administration of anti-CD25 mAb leads to impaired alpha-galactosylceramide-mediated induction of IFN-gamma production in a murine model. Immunobiology 218(6): 851-859.

    • Schmitz I, Schneider C, Frohlich A, Frebel H, Christ D, Leonard WJ, Sparwasser T, Oxenius A, Freigang S, Kopf M (2013) IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection. PLoS Pathog 9(5): e1003362.

    • Worthington JJ, Klementowicz JE, Rahman S, Czajkowska BI, Smedley C, Waldmann H, Sparwasser T, Grencis RK, Travis MA (2013) Loss of the TGFbeta-Activating Integrin alphavbeta8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity. PLoS Pathog 9(10): e1003675.


    • Abel S, Luckheide N, Westendorf AM, Geffers R, Roers A, Muller W, Sparwasser T, Matuschewski K, Buer J, Hansen W (2012) Strong Impact of CD4+Foxp3+ Regulatory T Cells and Limited Effect of T Cell-Derived IL-10 on Pathogen Clearance during Plasmodium yoelii Infection. J Immunol 188(11): 5467-5477.

    • Auriemma M, Brzoska T, Klenner L, Kupas V, Goerge T, Voskort M, Zhao Z, Sparwasser T, Luger TA, Loser K (2012) alpha-MSH-Stimulated Tolerogenic Dendritic Cells Induce Functional Regulatory T Cells and Ameliorate Ongoing Skin Inflammation. J Invest Dermatol 132(7): 1814-1824.

    • Baru AM, Ganesh V, Krishnaswamy JK, Hesse C, Untucht C, Glage S, Behrens G, Mayer CT, Puttur F, Sparwasser T (2012) Absence of Foxp3(+) Regulatory T Cells during Allergen Provocation Does Not Exacerbate Murine Allergic Airway Inflammation. PLoS One 7(10): e47102.

    • Baru AM, Untucht C, Ganesh V, Hesse C, Mayer CT, Sparwasser T (2012) Optimal Isolation of Functional Foxp3(+) Induced Regulatory T Cells Using DEREG Mice. PLoS One 7(9): e44760.

    • Berod L, Puttur F, Huehn J, Sparwasser T (2012) Tregs in infection and vaccinology: heroes or traitors?. Microb Biotechnol 5(2): 260-269.

    • Cervantes-Barragan L, Firner S, Bechmann I, Waisman A, Lahl K, Sparwasser T, Thiel V, Ludewig B (2012) Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection. J Immunol 188(8): 3678-3685.

    • Eberlein J, Davenport B, Nguyen TT, Victorino F, Sparwasser T, Homann D (2012) Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity. J Virol 86(4): 1955-1970.

    • Fyhrquist N, Lehtimaki S, Lahl K, Savinko T, Lappetelainen AM, Sparwasser T, Wolff H, Lauerma A, Alenius H (2012) Foxp3+ cells control th2 responses in a murine model of atopic dermatitis. J Invest Dematol 132(6): 1672-1680.

    • Gomez de Aguero M, Vocanson M, Hacini-Rachinel F, Taillardet M, Sparwasser T, Kissenpfennig A, Malissen B, Kaiserlian D, Dubois B (2012) Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8+ T cells and activating Foxp3+ regulatory T cells. J Clin Invest 122(5): 1700-1711.

    • Hansen W, Hutzler M, Abel S, Alter C, Stockmann C, Kliche S, Albert J, Sparwasser T, Sakaguchi S, Westendorf AM, Schadendorf D, Buer J, Helfrich I (2012) Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth. J Exp Med 209(11): 2001-2016.

    • Hansen W, Hutzler M, Abel S, Stockmann C, Albert J, Sparwasser T, Sakaguchi S, Westendorf A, Schadendorf D, Buer J, Helfrich I (2012) Neuropilin-1 deficiency on CD4+Foxp3+regulatory T cells impaires tumor growth in melanoma. Exp Dermatol 22(3): E38-E38.

    • Hellingman AA, van der Vlugt LE, Lijkwan MA, Bastiaansen AJ, Sparwasser T, Smits HH, Hamming JF, Quax PH (2012) A limited role for regulatory T cells in post-ischemic neovascularization. J Cell Mol Med 16(2): 328-336.

    • Krishnaswamy JK, Jirmo AC, Baru AM, Ebensen T, Guzman CA, Sparwasser T, Behrens GM (2012) TLR2 Agonist-Allergen Coupling Efficiently Redirects Th2 Cell Responses and Inhibits Allergic Airway Eosinophilia. Am J Respir Cell Mol Biol 47(6): 852-863.

    • Lehtimaeki S, Savinko T, Lahl K, Sparwasser T, Wolff H, Lauerma A, Alenius H, Fyhrquist N (2012) The Temporal and Spatial Dynamics of Foxp3+ Treg Cell-Mediated Suppression during Contact Hypersensitivity Responses in a Murine Model. J Invest Dermatol 132(12): 2744-2751.

    • Loebbermann J, Thornton H, Durant L, Sparwasser T, Webster KE, Sprent J, Culley FJ, Johansson C, Openshaw PJ (2012) Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol 5(2): 161-172.

    • Maazi H, Shirinbak S, Willart M, Hammad HM, Cabanski M, Boon L, Ganesh V, Baru AM, Hansen G, Lambrecht BN, Sparwasser T, Nawijn MC, van Oosterhout AJ (2012) Contribution of regulatory T cells to alleviation of experimental allergic asthma after specific immunotherapy. Clin Exp Allergy 42(10): 1519-1528.

    • Mayer CT, Berod L, Sparwasser T (2012) Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity. Front Immunol 3 183.

    • Mayer CT, Kuhl AA, Loddenkemper C, Sparwasser T (2012) Lack of Foxp3+ macrophages in both untreated and B16 melanoma-bearing mice. Blood 119(5): 1314-1315.

    • Navid F, Boniotto M, Walker C, Ahrens K, Proksch E, Sparwasser T, Muller W, Schwarz T, Schwarz A (2012) Induction of regulatory T cells by a murine beta-defensin. J Immunol 188(2): 735-743.

    • Ohkura N, Hamaguchi M, Morikawa H, Sugimura K, Tanaka A, Ito Y, Osaki M, Tanaka Y, Yamashita R, Nakano N, Huehn J, Fehling HJ, Sparwasser T, Nakai K, Sakaguchi S (2012) T cell receptor stimulation-induced epigenetic changes and foxp3 expression are independent and complementary events required for treg cell development. Immunity 37(5): 785-799.

    • Pace L, Tempez A, Arnold-Schrauf C, Lemaitre F, Bousso P, Fetler L, Sparwasser T, Amigorena S (2012) Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory. Science 338(6106): 532-536.

    • Panzer M, Sitte S, Wirth S, Drexler I, Sparwasser T, Voehringer D (2012) Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection. J Immunol 188(2): 615-623.

    • Reuter D, Sparwasser T, Hunig T, Schneider-Schaulies J (2012) Foxp3+ regulatory T cells control persistence of viral CNS infection. PloS One 7(3): e33989.

    • Schallenberg S, Petzold C, Tsai PY, Sparwasser T, Kretschmer K (2012) Vagaries of fluorochrome reporter gene expression in foxp3(+) regulatory T cells. PLoS One 7(8): e41971.

    • Schuster M, Glauben R, Plaza-Sirvent C, Schreiber L, Annemann M, Floess S, Kuhl AA, Clayton LK, Sparwasser T, Schulze-Osthoff K, Pfeffer K, Huehn J, Siegmund B, Schmitz I (2012) IkappaB(NS) Protein Mediates Regulatory T Cell Development via Induction of the Foxp3 Transcription Factor. Immunity 37(6): 998-1008.

    • Schwarz A, Navid F, Sparwasser T, Clausen BE, Schwarz T (2012) 1,25-Dihydroxyvitamin D Exerts Similar Immunosuppressive Effects as UVR but Is Dispensable for Local UVR-Induced Immunosuppression. J Invest Dermatol 132(12): 2762-2769.

    • Stross L, Gunther J, Gasteiger G, Asen T, Graf S, Aichler M, Esposito I, Busch DH, Knolle P, Sparwasser T, Protzer U (2012) Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute, experimental hepatitis B virus infection. Hepatology 56(3): 873-883.

    • Veiga-Parga T, Suryawanshi A, Mulik S, Gimenez F, Sharma S, Sparwasser T, Rouse BT (2012) On the Role of Regulatory T Cells during Viral-Induced Inflammatory Lesions. J Immunol 189(12): 5924-5933.

    • Zhao E, Wang L, Dai J, Kryczek I, Wei S, Vatan L, Altuwaijri S, Sparwasser T, Wang G, Keller ET, Zou W (2012) Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer. Oncoimmunology 1(2): 152-161.

    • van der Vlugt LE, Labuda LA, Ozir-Fazalalikhan A, Lievers E, Gloudemans AK, Liu KY, Barr TA, Sparwasser T, Boon L, Ngoa UA, Feugap EN, Adegnika AA, Kremsner PG, Gray D, Yazdanbakhsh M, Smits HH (2012) Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells. PloS One 7(2): e30883.


    • Arnold I, Lee J, Amieva M, Roers A, Flavell R, Sparwasser T, Muller A (2011) Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia. Gastroenterology 140(1): 199-209.

    • Baru AM, Krishnaswamy JK, Rathinasamy A, Scherr M, Eder M, Behrens GM (2011) Dendritic cells derived from HOXB4-immortalized hematopoietic bone marrow cells.. Exp Biol Med (Maywood) 236(11): 1291-1297.

    • Berod L, Heinemann C, Heink S, Escher A, Stadelmann C, Drube S, Wetzker R, Norgauer J, Kamradt T (2011) PI3Kgamma deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome.. Eur J Immunol 41(3): 833-844.

    • Beyer M, Thabet Y, Muller RU, Sadlon T, Classen S, Lahl K, Basu S, Zhou X, Bailey-Bucktrout SL, Krebs W, Schonfeld EA, Bottcher J, Golovina T, Mayer CT, Hofmann A, Sommer D, Debey-Pascher S, Endl E, Limmer A, Hippen KL, Blazar BR, Balderas R, Quast T, Waha A, Mayer G, Famulok M, Knolle PA, Wickenhauser C, Kolanus W, Schermer B, Bluestone JA, Barry SC, Sparwasser T, Riley JL, Schultze JL (2011) Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation.. Nat Immunol 12(9): 898-907.

    • Blankenhaus B, Klemm U, Eschbach ML, Sparwasser T, Huehn J, Kuhl AA, Loddenkemper C, Jacobs T, Breloer M (2011) Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice.. J Immunol 186(7): 4295-4305.

    • Cassani B, Villablanca EJ, Quintana FJ, Love PE, Lacy-Hulbert A, Blaner WS, Sparwasser T, Snapper SB, Weiner HL, Mora JR (2011) Gut-tropic T Cells that Express Integrin alpha4beta7 and CCR9 are Required for Induction of Oral Immune Tolerance in Mice.. Gastroenterology 141(6): 2109-18.

    • Dietze KK, Zelinskyy G, Gibbert K, Schimmer S, Francois S, Myers L, Sparwasser T, Hasenkrug KJ, Dittmer U (2011) Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points. Proc Nate Acad Sci 108(6): 2420-2425.

    • Hackl D, Loschko J, Sparwasser T, Reindl W, Krug AB (2011) Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs.. Eur J Immunol 41(5): 1334-1343.

    • Hadis U, Wahl B, Schulz O, Hardtke-Wolenski M, Schippers A, Wagner N, Muller W, Sparwasser T, Forster R, Pabst O (2011) Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria.. Immunity 34(2): 237-246.

    • Kastenmuller W, Gasteiger G, Subramanian N, Sparwasser T, Busch DH, Belkaid Y, Drexler I, Germain RN (2011) Regulatory T Cells Selectively Control CD8+ T Cell Effector Pool Size via IL-2 Restriction.. J Immunol 187(6): 3186-3197.

    • Lahl K, Sparwasser T (2011) In vivo depletion of Foxp3+ Tregs using the DEREG mouse model. Methods Mol Biol 707 157-172.

    • Lo Re S, Lecocq M, Uwambayinema F, Yakoub Y, Delos M, Demoulin JB, Lucas S, Sparwasser T, Renauld JC, Lison D, Huaux F (2011) PDGF-Producing CD4+ Foxp3+ Regulatory T Lymphocytes Promote Lung Fibrosis.. Am J Respir Crit Care Med 184(11): 1270-1281.

    • Lochner M (2011) Tertiary lymphoid tissues in the colon: friend and foe.. Gut Microbes 2(3): 193-197.

    • Lochner M, Berard M, Sawa S, Hauer S, Gaboriau-Routhiau V, Fernandez TD, Snel J, Bousso P, Cerf-Bensussan N, Eberl G (2011) Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells. J Immunol 186(3): 1531-1537.

    • Lochner M, Ohnmacht C, Presley L, Bruhns P, Si-Tahar M, Sawa S, Eberl G (2011) Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgt and LTi cells. J Exp Med 208(1): 125-134.

    • Mayer CT, Floess S, Baru AM, Lahl K, Huehn J, Sparwasser T (2011) CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity. Eur J Immunol 41(3): 716-725.

    • McNally A, Hill GR, Sparwasser T, Thomas R, Steptoe RJ (2011) CD4+CD25+regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis.. Proc Natl Acad Sci U S A 108(18): 7529-7534.

    • Navarro S, Cossalter G, Chiavaroli C, Kanda A, Fleury S, Lazzari A, Cazareth J, Sparwasser T, Dombrowicz D, Glaichenhaus N, Julia V (2011) The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways. Mucosal Immunol 4(1): 53-65.

    • Ohnmacht C, Marques R, Presley L, Sawa S, Lochner M, Eberl G (2011) Intestinal microbiota, evolution of the immune system and the bad reputation of proinflammatory immunity.. Cell Microbiol 13(5): 653-659.

    • Olivier A, Sainz-Perez A, Dong H, Sparwasser T, Majlessi L, Leclerc C (2011) The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells.. Eur J Immunol 41(8): 2303-2313.

    • Onder L, Scandella E, Chai Q, Firner S, Mayer CT, Sparwasser T, Thiel V, Rülicke T, Burkhard L (2011) Assessing stromal cell antigen presentation in a novel podoplanin: Cre-recombinase BAC-transgenic mouse model.. Front Immunol 2 50.

    • Pellegrini M, Calzascia T, Toe JG, Preston SP, Lin AE, Elford AR, Shahinian A, Lang PA, Lang KS, Morre M, Assouline B, Lahl K, Sparwasser T, Tedder TF, Paik J, DePinho RA, Basta S, Ohashi PS, Mak TW (2011) IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell 144(4): 601-613.

    • Sawa S, Lochner M, Satoh-Takayama N, Dulauroy S, Berard M, Kleinschek M, Cua D, Di Santo JP, Eberl G (2011) RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota.. Nat Immunol 12(4): 320-326.

    • Schwarz A, Navid F, Sparwasser T, Clausen BE, Schwarz T (2011) In vivo reprogramming of UV radiation-induced regulatory T-cell migration to inhibit the elicitation of contact hypersensitivity.. J Allergy Clin Immunol 128(4): 826-833.

    • Seung E, Cho JL, Sparwasser T, Medoff BD, Luster AD (2011) Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection.. J Immunol 186(12): 6830-6838.

    • Stagg J, Divisekera U, Duret H, Sparwasser T, Teng MW, Darcy PK, Smyth MJ (2011) CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis.. Cancer Res 71(8): 2892-2900.

    • Tacken PJ, Ginter W, Berod L, Cruz LJ, Joosten B, Sparwasser T, Figdor CG, Cambi A (2011) Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation. Blood 118(15): 4111-4119.

    • Tse BW, Russell PJ, Lochner M, Forster I, Power CA (2011) IL-18 Inhibits Growth of Murine Orthotopic Prostate Carcinomas via Both Adaptive and Innate Immune Mechanisms.. PLoS One 6(9): e24241.

    • Vaeth M, Gogishvili T, Bopp T, Klein M, Berberich-Siebelt F, Gattenloehner S, Avots A, Sparwasser T, Grebe N, Schmitt E, Hunig T, Serfling E, Bodor J (2011) Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Proc Natl Acad Sci U S A 108(6): 2480-2485.

    • Weiss EM, Schmidt A, Vobis D, Garbi N, Lahl K, Mayer CT, Sparwasser T, Ludwig A, Suri-Payer E, Oberle N, Krammer PH (2011) Foxp3-mediated suppression of CD95L expression confers resistance to activation-induced cell death in regulatory T cells.. J Immunol 187(4): 1684-1691.

    • Wheeler K, Tardif S, Rival C, Luu B, Bui E, Del Rio R, Teuscher C, Sparwasser T, Hardy D, Tung KS (2011) Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy.. Proc Natl Acad Sci U S A 108(18): 7511-7516.

    • Wilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M, Lahl K, Sparwasser T, Helmby H, Stockinger B (2011) An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation.. Nat Immunol 12(11): 1071-1077.

    • Woller N, Knocke S, Mundt B, Gurlevik E, Struver N, Kloos A, Boozari B, Schache P, Manns MP, Malek NP, Sparwasser T, Zender L, Wirth TC, Kubicka S, Kuhnel F (2011) Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice.. J Clin Invest 121(7): 2570-2582.


    • Anz D, Koelzer VH, Moder S, Thaler R, Schwerd T, Lahl K, Sparwasser T, Besch R, Poeck H, Hornung V, Hartmann G, Rothenfusser S, Bourquin C, Endres S (2010) Immunostimulatory RNA blocks suppression by regulatory T cells. J Immunol 184(2): 939-946.

    • Baru AM, Hartl A, Lahl K, Krishnaswamy JK, Fehrenbach H, Yildirim A, Garn H, Renz H, Behrens G, Sparwasser T (2010) Selective depletion of Foxp3+ regulatory T cells during sensitization phase aggravates experimental allergic airway inflammation. J Immunol 40(8): 2259-2266.

    • Boissonnas A, Scholer-Dahirel A, Simon-Blancal V, Pace L, Valet F, Kissenpfennig A, Sparwasser T*, Malissen B, Fetler L, Amigorenga S (2010) FoxP3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes. Immunity 32(2): 266-278.

    • Engel D, Koscielny A, Wehner S, Maurer J, Schiwon M, Franken L, Schumak B, Limmer A, Sparwasser T, Hirner A, Knolle P, Kalff J, Kurts C (2010) Th1 memory cells disseminate postoperative ileus over the entire intestinal tract. Nat Med 16(12): 1407-1713.

    • Haque A, Best SE, Amante FH, Mustafah S, Desbarrieres L, Labastida FD, Sparwasser T, Hill GR, Engwerda CR (2010) CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo. PloS Pathogens 6(12): e1001221.

    • Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F, Koch-Nolte F, Boyer O, Seman M, Adriouch S (2010) Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2/P2X7 pathway.. JEM 207(12): 2561-2568.

    • Klages K, Mayer CT, Lahl K, Loddenkemper C, Teng MW, Ngiow SF, Smyth MJ, Hamann A, Huehn J, Sparwasser T (2010) Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Research 70(20): 7788-7799.

    • Pechloff K, Holch J, Ferch U, Schweneker M, Kremer M, Sparwasser T, Quintanilla-Martinez L, Gewies A, Peschel C, Ruland J (2010) The fusion kinase ITK-SYK mimics a T-cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T-cell lymphoma. J Exp Med 207(5): 1031-1044.

    • Sawa S, Cherrier M, Lochner M, Satoh-Takayama N, Fehling HJ, Langa F, Di Santo JP, Eberl G (2010) Lineage relationship analysis of RORgammat+ innate lymphoid cells. Science 330(6004): 665-669.

    • Schildknecht A, Brauer S, Brenner C, Lahl K, Schild H, Sparwasser T*, Probst HC*, van den Broek M* (2010) FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T cell tolerance induced by steady state dendritic cells. Proc Nate Acad Sci 107(1): 199-203.

    • Suttner K, Depner M, Klopp N, von Mutius E, Illig T, Sparwasser T, Kabesch M (2010) Genetic variants harbouring the FOXP3 locus increase hay fever risk. J Allergy Clin Immunol 125(6): 1395-1399.

    • Teng MW, Ngiow SF, von Scheidt B, McLaughlin N, Sparwasser T, Smyth MJ (2010) Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth.. Cancer Research 70(20): 7800-7809.


    • Hamm S, Latz E, Hangel D, Mueller T, Yu P, Golenbock D, Sparwasser T, Wagner H, Bauer S (2009) Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist. Immunobiology 215(7): 559-569.

    • Kim J, Lahl K, Hori S, Loddenkemper C, Chaudhry A, Deroos P, Rudensky A, Sparwasser T (2009) Cutting Edge: Depletion of Foxp3+ Cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J Immunol 183(12): 7631-7634.

    • Lahl K, Mayer C, Bopp T, Huehn J, Loddenkemper C, Eberl G, Wirnsberger G, Dornmair K, Geffers R, Schmitt E, Buer J, Sparwasser T (2009) Nonfunctional regulatory T cells and defective control of Th2 Cytokine production in natural scurfy mutant mice. J Immunol 183(9): 5662-5672.

    • Pellegrini M, Calzascia T, Elford AR, Shahinian A, Lin AE, Dissanayake D, Dhanji S, Nguyen LT, Gronski MA, Morre M, Assouline B, Lahl K, Sparwasser T, Ohashi PS, Mak TW (2009) Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nat Med 15(5): 528-536.

    • Rausch S, Huehn J, Loddenkemper C, Hepworth MR, Klotz C, Sparwasser T, Hamann A, Lucius R, Hartmann S (2009) Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3(+) Cells. Eur J Immunol 39(11): 3066-3077.

    • Siegemund S, Hartl A, von Buttlar H, Dautel F, Raue R, Freudenberg MA, Fejer G, Buttner M, Koehler G, Kirschning CJ, Sparwasser T, Alber G (2009) Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis. J Virol 83(18): 9411-9422.

    • Singh S, Stephani J, Schaefer M, Kalay H, Garcia-Vallejo JJ, den Haan J, Saeland E, Sparwasser T, van Kooyk Y (2009) Targeting glycan modified OVA to murine DC-SIGN-transgenic dendritic cells enhances MHC class I and II presentation. Molecular Immunol 47(2-3): 164-174.

    • Steeg C, Adler G, Sparwasser T, Fleischer B, Jacobs T (2009) Limited role of CD4+Foxp3+ regulatory T cells in the control of experimental cerebral malaria. J Immunol 183(11): 7014-7022.

    • Zelinskyy G, Dietze K, Huesecken YP, Schimmer S, Nair S, Werner T, Gibbert K, Kershaw O, Gruber AD, Sparwasser T, Dittmer U (2009) The regulatory T cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T cell response. Blood 114(15): 3199-3207.

    • Zelinskyy G, Dietze K, Sparwasser T, Dittmer U (2009) Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus. PloS Pathogens 5(8): e1000406.

    • von Allmen CE, Schmitz N, Bauer M, Hinton HJ, Kurrer M, Buser RB, Gwerder M, Muntwiler S, Sparwasser T, Beerli RR, Bachmann MF (2009) Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells. Proc Nate Acad Sci 106(28): 11673-11678.


    • Heit A, Gebhardt F, Lahl K, Neuenhahn M, Schmitz F, Anderl F, Wagner H, Sparwasser T*, Busch DH, Kastenmuller K* (2008) Circumvention of regulatory CD4(+) T cell activity during cross-priming strongly enhances T cell-mediated immunity. Eur J Immunol 38(6): 1585-1597.

    • Osorio F, LeibundGut-Landmann S, Lochner M, Lahl K, Sparwasser T, Eberl G, Reis E, Sousa C (2008) DC activated via dectin-1 convert Treg into IL-17 producers. Eur J Immunol 38(12): 3274-3281.

    • Schaefer M, Reiling N, Fessler C, Stephani J, Taniuchi I, Hatam F, Yildirim AO, Fehrenbach H, Walter K, Ruland J, Wagner H, Ehlers S, Sparwasser T (2008) Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection. J Immunol 180(10): 6836-6845.


    • Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, Eberl G, Hamann A, Wagner H, Huehn J, Sparwasser T (2007) Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 204(1): 57-63.

    • Sparwasser T, Eberl G (2007) BAC to immunology--bacterial artificial chromosome-mediated transgenesis for targeting of immune cells. Immunology 121(3): 308-313.


    • Gross O, Gewies A, Finger K, Schafer M, Sparwasser T, Peschel C, Forster I, Ruland J (2006) Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442(7103): 651-656.

    • Klemm S, Gutermuth J, Hultner L, Sparwasser T, Behrendt H, Peschel C, Mak TW, Jakob T, Ruland J (2006) The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation.. J Exp Med 203(2): 337-347.

    • von Meyenn F, Schaefer M, Weighardt H, Bauer S, Kirschning CJ, Wagner H, Sparwasser T (2006) Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guerin by Flt3-ligand generated dendritic cells. Immunobiology 211(6-8): 557-565.


    • Sparwasser T, Gong S, Li JY, Eberl G (2004) General method for the modification of different BAC types and the rapid generation of BAC transgenic mice. Genesis 38(1): 39-50.


    • Jung S, Unutmaz D, Wong P, Sano G, De los Santos K, Sparwasser T, Wu S, Vuthoori S, Ko K, Zavala F, Pamer EG, Littman DR, Lang RA (2002) In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 17(2): 211-220.


    • Baribaud F, Pohlmann S, Sparwasser T, Kimata MT, Choi YK, Haggarty BS, Ahmad N, Macfarlan T, Edwards TG, Leslie GJ, Arnason J, Reinhart TA, Kimata JT, Littman DR, Hoxie JA, Doms RW (2001) Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN. J Virol 75(21): 10281-10289.


    • Decker T, Schneller F, Sparwasser T, Tretter T, Lipford GB, Wagner H, Peschel C (2000) Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood 95(3): 999-1006.

    • Lipford GB, Sparwasser T (2000) Hematopoietic remodeling triggered by CpG DNA. Curr Top Microbiol Immunol 247 119-129 Review.

    • Lipford GB, Sparwasser T, Zimmermann S, Heeg K, Wagner H (2000) CpG-DNA-mediated transient lymphadenopathy is associated with a state of Th1 predisposition to antigen-driven responses. J Immunol 165(3): 1228-1235.

    • Sparwasser T, Lipford GB (2000) Consequences of bacterial CpG DNA-driven activation of antigen-presenting cells. Curr Top Microbiol Immunol 247 59-75 Review.

    • Sparwasser T, Vabulas RM, Villmow B, Lipford GB, Wagner H (2000) Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins. Curr Top Microbiol Immunol 30(12): 3591-3597.


    • Sparwasser T, Hultner L, Koch ES, Luz A, Lipford GB, Wagner H (1999) Immunostimulatory CpG-oligodeoxynucleotides cause extramedullary murine hemopoiesis. J Immunol 162(4): 2368-74.


    • Hacker H, Mischak H, Miethke T, Liptay S, Schmid R, Sparwasser T, Heeg K, Lipford GB, Wagner H (1998) CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. Embo J 17(21): 6230-6240.

    • Heeg K, Sparwasser T, Lipford GB, Hacker H, Zimmermann S, Wagner H (1998) Bacterial DNA as an evolutionary conserved ligand signalling danger of infection to immune cells. Eur J Clin Microbiol Infect Dis 17(7): 464-469.

    • Sparwasser T, Koch ES, Vabulas RM, Heeg K, Lipford GB, Ellwart JW, Wagner H (1998) Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 28(6): 2045-2054.


    • Lipford GB, Sparwasser T, Bauer M, Zimmermann S, Koch ES, Heeg K, Wagner H (1997) Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines. Eur J Immunol 27(12): 3420-3426.

    • Sparwasser T, Miethke T, Lipford G, Borschert K, Hacker H, Heeg K, Wagner H (1997) Bacterial DNA causes septic shock. Nature 386(6623): 336-337.

    • Sparwasser T, Miethke T, Lipford GB, Erdmann A, Hacker H, Heeg K, Wagner H (1997) Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock. Eur J Immunol 27(7): 1671-1679.