Better results through less stress
Researchers in Hannover have developed a new method for studying neuroinfections. This reduces errors in analysis and delivers more accurate results.
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Infection research at the interface between clinical practice and basic research
At TWINCORE, we combine the expertise of medical professionals and scientists from a wide range of disciplines to find answers to the pressing questions in infection research. Our focus: translational research – the bridge between basic science and clinical application.
Apply for LISA 2025
Registration for the Lower Saxony International Summer Academy 2025 is open until 2025.
Find more information here!
New approaches to research into systemic sclerosis
A research team at TWINCORE was able to establish that TLR8 influences the formation of disease-relevant cytokines.
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More than the sum of the parts
TWINCORE researchers show role of epistatic interaction in the omicron variant of SARS-CoV-2 virus .
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We conduct translational infection research to improve the prevention, diagnosis and treatment of infectious diseases in humans. We focus on three areas that characterize our research work. Find out here how we proceed and what results we achieve.
Immunology
Virology
Bacteriology
Labs at TWINCORE
Under the leadership of our best scientists, various labs are working on different projects within our research topics.
2024PLoS Pathog
Deep mining of the Sequence Read Archive reveals major genetic innovations in coronaviruses and other nidoviruses of aquatic vertebrates
C Lauber, X Zhang, J Vaas, F Klingler, P Mutz, A Dubin, T Pietschmann, O Roth, B W Neuman, A E Gorbalenya, R Bartenschlager, S Seitz
2024Transpl Int
In Vitro Profiling of Commonly Used Post-transplant Immunosuppressants Reveals Distinct Impact on Antiviral T-cell Immunity Towards CMV
M B Krueger, A Bonifacius, A C Dragon, M M Santamorena, B Nashan, R Taubert, U Kalinke, B Maecker-Kolhoff, R Blasczyk, B Eiz-Vesper
in pressEur J Immunol
Diversification of the VH3‐53 immunoglobulin gene segment by somatic hypermutation results in neutralization of SARS‐CoV‐2 virus variants
M Bruhn, M Obara, A Salam, B Costa, A Ziegler, I Waltl, A Pavlou, M Hoffmann, T Graalmann, S Pöhlmann, A Schambach, U Kalinke
Graalmann Lab
Immunology
Tissue inflammation upon chronic rheumatic diseases
Patients with chronic rheumatic diseases have an increased risk of infection due to severe inflammation. This project investigates inflammation in various tissues, particularly in systemic sclerosis, in order to develop targeted therapies.
Graalmann Lab
Immunology
Indirect effects of immunomodulatory drugs
Immunomodulatory drugs for rheumatic diseases specifically influence immune cells and messenger substances. This project investigates their effect on immune responses in order to find individually suitable therapies.
Graalmann Lab
Immunology
Cell-selective targeting of immune cells
Immunomodulatory drugs can have systemic side effects. This project is testing nanocarriers that deliver drugs specifically into myeloid immune cells in order to reduce side effects and increase the local effect.
Kalinke Lab
Immunology
Immunological sensing of cytomegalovirus (CMV)
The project investigates how HCMV is recognized by the immune system and which mechanisms the virus uses to camouflage itself. The aim is to understand the immune reactions and develop therapies for severely affected patients.
There are currently no events.
Career at TWINCORE
Want to become part of TWINCORE?
Take a look at our job advertisements to see if there is something suitable for you or send us an unsolicited application.
